Quantitative cardiovascular magnetic resonance: extracellular volume, native T1 and 18F-FDG PET/CMR imaging in patients after revascularized myocardial infarction and association with markers of myocardial damage and systemic inflammation

Kunze, Karl; Dirschinger, Ralf J.; Kossmann, Hans; Hanus, Franziska; Ibrahim, Tareq; Laugwitz, Karl‐Ludwig; Schwaiger, Markus; Rischpler, Christoph; Nekolla, Stephan G.

doi:10.1186/s12968-018-0454-y

Cited by 20 publications

(17 citation statements)

References 30 publications

(38 reference statements)

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“…Cardiac positron emission tomography (PET) can also measure myocardial metabolic reaction kinetics through the uptake of tracers . It is able to confirm viability in suspected hibernating myocardium using glucose tracers . PET is able to detect uptake in ingressing inflammatory cells and has emerging roles in the detection of prosthetic valve endocarditis and inflammatory atherosclerotic coronary and carotid plaques .…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac MR(S) and PET measure similar information with differing trade‐offs in temporal and spatial resolution. The use of both in tandem could offer complementary information …”

Section: Discussionmentioning

confidence: 99%

“…29 It is able to confirm viability in suspected hibernating myocardium using glucose tracers. 30 PET is able to detect uptake in ingressing inflammatory cells and has emerging roles in the detection of prosthetic valve endocarditis 31 and inflammatory atherosclerotic coronary and carotid plaques. 32,33 However, the onward metabolism of the tracer after uptake cannot be assessed and it is not possible to distinguish which cell type is responsible using PET alone.…”

Section: Discussionmentioning

confidence: 99%

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Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T

et al. 2019

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Changes in the kinetics of the creatine kinase (CK) shuttle are sensitive markers of cardiac energetics but are typically measured at rest and in the prone position. This study aims to measure CK kinetics during pharmacological stress at 3 T, with measurement in the supine position. A shorter “stressed saturation transfer” (StreST) extension to the triple repetition time saturation transfer (TRiST) method is proposed. We assess scanning in a supine position and validate the MR measurement against biopsy assay of CK activity. We report normal ranges of stress CK forward rate (k f CK ) for healthy volunteers and obese patients. TRiST measures k f CK in 40 min at 3 T. StreST extends the previously developed TRiST to also make a further k f CK measurement during <20 min of dobutamine stress. We test our TRiST implementation in skeletal muscle and myocardium in both prone and supine positions. We evaluate StreST in the myocardium of six healthy volunteers and 34 obese subjects. We validated MR‐measured k f CK against biopsy assays of CK activity. TRiST k f CK values matched literature values in skeletal muscle (k f CK = 0.25 ± 0.03 s −1 vs 0.27 ± 0.03 s −1 ) and myocardium when measured in the prone position (0.32 ± 0.15 s −1 ), but a significant difference was found for TRiST k f CK measured supine (0.24 ± 0.12 s −1 ). This difference was because of different respiratory‐ and cardiac‐motion‐induced B 0 changes in the two positions. Using supine TRiST, cardiac k f CK values for normal‐weight subjects were 0.15 ± 0.09 s −1 at rest and 0.17 ± 0.15 s −1 during stress. For obese subjects, k f CK was 0.16 ± 0.07 s −1 at rest and 0.17 ± 0.10 s −1 during stress. Rest myocardial k f CK and CK activity from LV biopsies of the same subjects correlated ( R = 0.43, p = 0.03). We present an independent implementation of TRiST on the Siemens platform using a commercially available coil. Our extended StreST protocol enables cardiac k f CK to be measured during dobutamine‐induced stress in the supine position.

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Section: Discussionmentioning

confidence: 99%

“…Cardiac MR(S) and PET measure similar information with differing trade‐offs in temporal and spatial resolution. The use of both in tandem could offer complementary information …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T

et al. 2019

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“…Nonetheless, LGE by MRI and missing or elevated [ 18 F]FDG uptake often represent the same pathophysiological imaging targets, such as myocardial infarction or necrosis in the case of myocarditis. This might change when quantitative imaging by MRI and/or more specific tracers in PET are used …”

Section: Discussionmentioning

confidence: 99%

“…This might change when quantitative imaging by MRI and/or more specific tracers in PET are used. 20,21 Sympathetic cardiac reinnervation is a known phenomenon after cardiac transplant, which becomes assessable by orthostatic stress 5 months after transplant based on assessment of heart rate variability. 22 Further, studies have shown that possible reinnervation seems to increase over time (as shown by [ 123 I]meta-iodobenzylguanidine ([ 123 I]MIBG) uptake in scintigraphy).…”

Section: Discussionmentioning

confidence: 99%

Assessment of sympathetic reinnervation after cardiac transplantation using hybrid cardiac PET/MRI: A pilot study

Beitzke

Wielandner

Wollenweber

et al. 2019

Magnetic Resonance Imaging

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Background Sympathetic reinnervation after heart transplantation (HTX) is a known phenomenon, which has an impact on patient heart rate variability and exercise capacity. The impact of reinnervation on myocardial structure has not been evaluated yet. Propose To evaluate the feasibility of simultaneous imaging of cardiac reinnervation and cardiac structure using a hybrid PET/MRI system. Study type Prospective / pilot study. Subjects Ten patients, 4–21 years after cardiac transplantation. Field Strength/Sequence 3 T hybrid PET/MRI system. Cine SSFP, T1 mapping (modified Look–Locker inversion recovery sequence) pre/postcontrast as well as dynamic [11C]meta‐hydroxyephedrine ([11C]mHED) PET. Assessment All MRI and PET parameters were evaluated by experienced readers using dedicated postprocessing software packages for cardiac MRI and PET. For all parameters a 16‐segment model for the left ventricle was applied. Statistical Tests Mann–Whitney U‐test; Spearman correlations. Results Thirty‐six of 160 myocardial segments showed evidence of reinnervation by PET. On a segment‐based analysis, mean native T1 relaxation times were nonsignificantly altered in segments with evidence of reinnervation (1305 ± 151 msec vs. 1270 ± 112 msec; P = 0.1), whereas mean extracellular volume (ECV) was significantly higher in segments with evidence of reinnervation (35.8 ± 11% vs. 30.9 ± 7%; P = 0.019). There were no significant differences in wall motion (WM) and wall thickening (WT) between segments with or without reinnervation (mean WM: 7.6 ± 4 mm vs. group B: 9.3 ± 7 mm [P = 0.13]; WT: 79 ± 63% vs. 94 ± 74% [P = 0.27]) under resting conditions. Data Conclusion The assessment of cardiac reinnervation using a hybrid PET/MRI system is feasible. Segments with evidence of reinnervation by PET showed nonsignificantly higher T1 relaxation times and a significantly higher ECV, suggesting a higher percentage of diffuse fibrosis in these segments, without impairment of rest WM and WT. Level of Evidence: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:1326–1335.

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Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

Koh

Kovalik

2021

ESC Heart Failure

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The purpose of this review is to explore how metabolomics can help uncover new biomarkers and mechanisms for cardiovascular ageing. Cardiovascular ageing refers to cardiovascular structural and functional alterations that occur with chronological ageing and that can lead to the development of cardiovascular disease. These alterations, which were previously only detectable on tissue histology or corroborated on blood samples, are now detectable with modern imaging techniques. Despite the emergence of powerful new imaging tools, clinical investigation into cardiovascular ageing is challenging because ageing is a life course phenomenon involving known and unknown risk factors that play out in a dynamic fashion. Metabolomic profiling measures large numbers of metabolites with diverse chemical properties. Metabolomics has the potential to capture changes in biochemistry brought about by pathophysiologic processes as well as by normal ageing. When combined with non-invasive cardiovascular imaging tools, metabolomics can be used to understand pathological consequences of cardiovascular ageing. This review will summarize previous metabolomics and imaging studies in cardiovascular ageing. These methods may be a clinically relevant and novel approach to identify mechanisms of cardiovascular ageing and formulate or personalize treatment strategies.

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Quantitative cardiovascular magnetic resonance: extracellular volume, native T1 and 18F-FDG PET/CMR imaging in patients after revascularized myocardial infarction and association with markers of myocardial damage and systemic inflammation

Cited by 20 publications

References 30 publications

Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T

Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T

Assessment of sympathetic reinnervation after cardiac transplantation using hybrid cardiac PET/MRI: A pilot study

Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

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