Quantitative butyrylcholinesterase activity detection by surface-enhanced Raman spectroscopy

Human angiotensin I‐converting enzyme study by surface‐enhanced Raman spectroscopy

“…[ 14 ] Qualitative and quantitative analysis of low‐molecular analytes and proteins can be carried out using SERS spectra and multivariate statistics. [ 17–20 ]…”

“…[14] Qualitative and quantitative analysis of low-molecular analytes and proteins can be carried out using SERS spectra and multivariate statistics. [17][18][19][20] The first SERS studies of macromolecular substances were undertaken in the 1980s. [21,22] Their practical application was limited by the lack of theoretical understanding of the nature of the effect.…”

“…[23] Today, there are a number of works related to the analysis of high molecular weight substances by the SERS method, including proteins, for example, serum albumin, myoglobin, and butyrylcholinesterase. [17,19,20,24] Positive results indicate that the method can be used to analyze a wide range of proteins. It is worth noting the possibility of using SERS to refine the structure of molecules.…”

Patterned Superhydrophobic SERS Substrates for Sample Pre-Concentration and Demonstration of Its Utility through Monitoring of Inhibitory Effects of Paraoxon and Carbaryl on AChE

“…More recently, there were also reports on a similar colloid/acetylcholine system with the additional emphasis on the state of colloid aggregation [48] and a cautionary note on the effect of silver nanoparticles on hydrolysis [49]. A closely related enzyme, butyrylcholinesterase, was also investigated with SERS using silver paste [50].…”

Investigation on the relationship between violent death, cocaine abuse and single nucleotide polymorphisms

“…BChE levels -either increased or decreased -may be an indicator of disease or intoxication(NECHAEVA et al, 2018).Even though its precise physiological function is still unclear, this enzyme is rather important in the field of toxicology, as it is responsible for hydrolysing estercontaining drugs (NECHAEVA et al, 2018). Based on this knowledge, Negrão and colleagues have looked at the three SNPs from the BCHE gene (rs1803274, rs4263329 and rs4680662) in a Brazilian population, as variations in this gene may alter BChE's catalytic activity, resulting in a potential susceptibility to dependence(NEGRÃO et al, 2013).The proposed hypothesis was based on the fact that users containing polymorphisms in the BCHE gene may show distinct addictive behaviours due to differences in effective plasma concentrations of cocaine.…”