Quantitative bone scan imaging using BSI and BUV: an approach to evaluate ARONJ early

Yamamoto, Yayoi; Mitsunaga, Sachiyo; Horikawa, Ayumi; Hino, Ayako; Kurihara, Hiroaki

doi:10.1007/s12149-019-01417-x

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Currently, visual analysis has been the primary analytic method for bone scintigraphy. However, visual analysis is subjective and is dependent on the clinical experience of the reader, and previous studies have reported a moderate degree of inter-rater agreement in the interpretation of bone scintigraphy images with kappa values between 0.48-0.54 [9,13,14]. Similarly, we observed a moderate degree of agreement (kappa value of 0.597) between both the readers in joint uptake classification.…”

Section: Discussionsupporting

confidence: 62%

“…Although it has a high sensitivity for the detection of joint involvement in various joint disorders, its potential clinical benefits for evaluating arthritis involvement in individuals with joint symptoms remain contentious [1,[5][6][7][8]. This may be due to the existing primary method of bone scintigraphy interpretation, visual assessment, that has involved significant inter-reader discrepancies limiting the general and objective application [6,9]. Therefore, there is a need for an objective quantitative analytic method for bone scintigraphy image interpretations [6,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…This may be due to the existing primary method of bone scintigraphy interpretation, visual assessment, that has involved significant inter-reader discrepancies limiting the general and objective application [6,9]. Therefore, there is a need for an objective quantitative analytic method for bone scintigraphy image interpretations [6,[9][10][11]. In patients Diagnostics 2020, 10, 1000 2 of 13 with bone metastasis, bone scan index, which is a quantitative parameter for the extent of bone metastasis that is automatically calculated using dedicated software, has been introduced as an imaging biomarker of bone metastasis and its use has gradually increased [4,11].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Use of Quantitative Analysis of Bone Scintigraphy to Assess the Involvement of Arthritis Diseases in Patients with Joint Symptoms

et al. 2020

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We aimed to compare the diagnostic ability of quantitative analysis of bone scintigraphy with that of visual analysis for identifying arthritis disease involvement in patients with joint symptoms. We retrospectively included 93 patients with joint symptoms who underwent Tc-99m methylene diphosphonate bone scintigraphy for evaluating arthritis disease involvement. Bone scintigraphy images were visually and quantitatively analyzed using an in-house software by two reviewers. On quantitative analysis, joint uptake ratio was measured for 64 joints in 14 joints areas. The inter-rater agreement of visual and quantitative analyses was assessed, and diagnostic abilities were compared based on the area under the receiver operating characteristic (ROC) curve (AUC) values. Regarding visual analysis, there was a moderate degree of inter-rater agreement (kappa coefficient of 0.597), while there was a substantial inter-rater agreement (concordance correlation coefficient of 0.987) in the measurement of the joint uptake ratio. The comparisons of ROC curves for the total 5941 joints revealed that the joint uptake ratio had a significantly higher AUC value (0.789) to detect the affected joint than that of the visual analysis (p < 0.001). Quantitative analysis using joint uptake ratio showed substantial reproducibility and higher diagnostic ability to detect joints involving arthritis diseases than visual analysis on bone scintigraphy.

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Section: Discussionsupporting

confidence: 62%