Quantitative Bestimmung der individuellen zellularen Immunantwort

Hermann, G.; Dostal, G.; Sesterhenn, K.

doi:10.1007/bf00590695

Cited by 4 publications

(3 citation statements)

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“…Unlike xenorosette formation, allorosettes cannot be produced by red blood cell immunization, and there are no spontaneous A R F C [18,19]. After renal transplantation, A R F C increase up to day 8 after transplantation, when the kidney transplant is rejected and destroyed [20].…”

Section: Introductionmentioning

confidence: 99%

“…Allorosettes were found to appear after renal transplantation [8,[18][19][20], skin transplantation [16,[25][26][27], or immunization with spleen cells [22,34] and tumor cells [7] between isohistogenic strains of rats and mice. Unlike xenorosette formation, allorosettes cannot be produced by red blood cell immunization, and there are no spontaneous A R F C [18,19].…”

Section: Introductionmentioning

confidence: 99%

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The nature of allorosette-forming cells in rats

Lempfrid

Hermann

1982

Res. Exp. Med.

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ARFC appear in the spleen after transplantation of organs or tissues and immunization with nucleated cells between isohistogenic rat strains. The allorosette formation of rat spleen cells and T cells, isolated by an Ig-anti-Ig column, was examined. It has been demonstrated that 90% of ARFC are B cells and 10% are T cells. The allorosette phenomenon can therefore be considered an immune reaction concerning predominantly the B-cell system. Allorosette-forming T cells are discussed to be SD-antigen-recognizing cytotoxic T cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The nature of allorosette-forming cells in rats

Lempfrid

Hermann

1982

Res. Exp. Med.

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“…Ebenso traten rosettenbildende Zellen (Allo-Rosetten) 7 auf, die den Verlauf der IA quantitativ anzeigten, wenn Nieren yon Sprague-Dawley-Ratten transplantiert wurden (13,14). Dabei wurde die ICA mit isolierten MZ der Empfgngertiere und den konservierten Ery der entsprechenden Spender durchgefUhrt.…”

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Allorosettes after renal transplantation in inbred strains of rats

Sesterhenn

Dostal²,

Mohr³

et al. 1977

Res. Exp. Med.

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33 renal transplantations in the isohistogeneic rat strains DA/Han and BDE/Han were performed. The transplanted animals were killed at different days after transplantation and the following dates investigated: 1. number of rosette forming spleen cells with donor erythrocytes, calculated for 10,000 spleen cells and to the total number of extracted spleen cells, 2. haemagglutinin titers with donor erythrocytes. 3. titers of serum IgG, 4. Total number of spleen cells, weight of spleens, weight and volumes of kidney transplants and the number of peripheral blood lymphocytes and granulocytes. The results deomonstrate that the method of immunocytoadherence as described by BIOZZI and ZAALBERG in xenogeneic transplantation systems can also be used in allogenic systems. The course of the immune response was biphasic. Quantitation of allorosette forming cells can be considered as a paramter of allograft rejection. The current literature as to the T- or B-cell specificity of rosetting cells is discussed.

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