Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power
            Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis
            of Sjögren""s Syndrome

Ustabaşıoğlu, Fethi Emre; Korkmaz, Selçuk; İlgen, Ufuk; Solak, Serdar; Kula, Osman; Turan, Sezin; Emmüngil, Hakan

doi:10.4274/balkanmedj.galenos.2020.2019.11.91

Cited by 12 publications

(21 citation statements)

References 22 publications

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“…Depending on the stage of the disease, glands can be enlarged or be of normal or reduced size. US was addressed as the most relevant diagnostic tool in SS, but also in general in sialadenitis caused by or related to the autoimmune-system, in textbooks [63,64] and multiple publications after examination of adults [67,78,[153][154][155][156][157][158][159][160][161] and children [56,61,62,[162][163][164]. In general the parenchyma has a mixed cystic or solid echo-texture with a "leopard-skin"-like or cloudy aspect.…”

Section: Sjoegren's Syndrome/diseasementioning

confidence: 99%

“…While techniques like tissue harmonic imaging (THI), power mode (PM), and colorcoded sonography (CCS) are part of examination routine [20,25,38,67], recent developments have pointed to new possibilities in the application of US [40], such as contrast-enhanced US (CEUS) [68][69][70][71][72], elastography [59,[73][74][75][76][77][78][79][80][81], and sonohistology [82,83].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature

Koch

Sievert

Iro

et al. 2021

JCM

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Background: Ultrasound is established as a diagnostic tool in salivary glands for obstructive diseases such as sialolithiasis and tumors. Concerning inflammatory diseases and in non-sialolithiasis-caused obstruction, much fewer data are available. In recent years, technical development has allowed a better assessment of the gland parenchyma, and knowledge about intraductal pathologies has increased considerably, which has provided new insights and a new interpretation of ultrasound findings. Objectives: To provide a comprehensive review of the literature that includes our own experiences and to point out the state of the art in ultrasound in the diagnostics of inflammatory and obstructive salivary gland diseases, taking adequate techniques and recent technical developments into consideration. Data sources and study eligibility criteria: A systematic literature search was performed in Pubmed using various specific key words. Results: According to the literature results, including our own experiences, ultrasound is of value in up to >90% of cases presenting with inflammatory and/or obstructive diseases. Technical developments (e.g., elastography) and the application of modified ultrasound techniques (e.g., transoral ultrasound) have contributed to these results. Today, ultrasound is considered a first-line diagnostic tool in these diseases. However, in some inflammatory diseases, the final diagnosis can be made only after inclusion of the anamnesis, clinical symptoms, serologic blood tests, or histopathologic investigation. Conclusions: Ultrasound can be considered as a first-line diagnostic tool in obstructive and inflammatory salivary gland diseases. In obstructive diseases, it may be sufficient for diagnostics in >90% of cases. In inflammatory diseases, ultrasound is at least an excellent screening method and can be used to establish the diagnosis in cases of an early suspicion. In all diseases ultrasound can contribute to better management and can be used for monitoring during follow-up.

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Section: Sjoegren's Syndrome/diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature

Koch

Sievert

Iro

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Recently, massive studies have demonstrated that grayscale ultrasound (US) could clearly display a subtle sonographic abnormality of the salivary glands (SGs) in pSS, including the glandular border, echostructure, and acoustic effects ( 13 , 14 ). Furthermore, color Doppler sonography (CDS) could reflect changes in glandular hemodynamics by evaluating microvascular vascularity index values in pSS ( 15 ). Although ultrasonographical techniques are highly operator- and observer-dependent, various scoring systems, including De Vita score ( 16 ), Hocevar score ( 17 ), Salaffi score ( 18 ), Jousse-Joulin score ( 10 ), and OMERACT semiquantitative score ( 19 ), have been used to evaluate the typical SGUS changes of pSS, and many efforts have been made in the assessment of consensus and reliability of these scores for pSS, even in European Union (EU)-funded projects ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Performance Evaluation of Multiple Ultrasonographical Methods for the Detection of Primary Sjögren’s Syndrome

Luo

Zhu

et al. 2021

Front. Immunol.

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Major salivary gland ultrasonography (SGUS) is increasingly being recognized as having critical roles in differentiating primary Sjögren’s syndrome (pSS) from other connective tissue disorders. Contrast-enhanced ultrasonography (CEUS) has been reported to evaluate microvascularity of lesions in different tissues with objective angiographic index, eliminating the observer-dependent defect of ultrasonography. However, there are few relevant studies concentrating on the application of CEUS in the diagnosis and assessment for pSS, and their clinical utility prospect remains uncertain. In this study, a total of 227 eligible patients were enrolled, including 161 pSS and 66 non-pSS patients with comprehensive ultrasonographic evaluation of the parotid and submandibular glands, including grayscale ultrasonography, color Doppler sonography (CDS), and CEUS. Compared with non-pSS, pSS patients had significantly higher grayscale ultrasound (US) scores and CDS blood grades in the parotid gland and significantly higher grayscale US and CEUS scores in the submandibular glands. Diagnostic model combining ultrasonographic signatures, anti-SSA/Ro60, and keratoconjunctivitis sicca (KCS) tests showed a remarkable discrimination [mean area under the curve (AUC)0.963 in submandibular glands and 0.934 in parotid glands] for pSS, and the nomogram provided excellent prediction accuracy and good calibration in individualized prediction of pSS. A combination of multiple ultrasonographical examinations of the major salivary glands (SGs) is a promising technique that may be used as a practical alternative to minor SG biopsy in the detection of pSS.

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“…The degree of renal parenchymal fibrosis and renal cortex microvascularization is of great importance in the development of hemorrhage; however, standardization has been achieved in various parameters such as hypertension, low glomerular filtration rate, anemia, age, and biopsy needle thickness, which are the main factors determining the bleeding risk in previous studies 6–8 . Superb microvascular imaging (SMI) and shear wave elastography (SWE) are techniques that are frequently used in the current literature to evaluate various tissues 9–13 . Ultrasound elastography is a current sonographic method that can detect the degree of hardness of tissues and tissue changes 14 .…”

mentioning

confidence: 99%

“…[6][7][8] Superb microvascular imaging (SMI) and shear wave elastography (SWE) are techniques that are frequently used in the current literature to evaluate various tissues. [9][10][11][12][13] Ultrasound elastography is a current sonographic method that can detect the degree of hardness of tissues and tissue changes. 14 There are 2 types of elastography techniques in routine use, strain elastography (tension) and SWE.…”

mentioning

confidence: 99%

The Role of Superb Microvascular Imaging and Shear Wave Elastography in the Prediction of Hemorrhage Complications After Renal Parenchyma Biopsy

Günay,

Uslu,

Çelik

et al. 2023

Ultrasound Quarterly

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Objectives The aim of study was to evaluate the diagnostic utility of the renal parenchyma elasticity with the shear wave elastography (SWE) and microvascularization with the superb microvascular imaging (SMI) technique before kidney biopsy and to predict the complication of hemorrhage before kidney biopsy. Methods A total of 75 patients were included in the prospective study. Before the biopsy, vascularity features of the kidney parenchyma in the area to be biopsied were assessed by SMI and parenchymal stiffness by SWE and were examined by 2 independent radiologists. Results A statistically significant difference was found in the SMI and SWE values between the groups with and without hematoma and hematuria when compared with the Student t test and Mann-Whitney U test (P < 0.05). The SWE hardness cutoff value, which maximizes the prediction of the development of hematuria, was found to be 18.40 kPa, and the sensitivity and specificity values were 84.4% and 62.8%, respectively. In SMI vascularity index values, the cutoff value was found to be 0.247410800 kPa, and sensitivity and specificity values were 81.3% and 83.7%, respectively. The cutoff value of the SMI vascularity index values that maximized the prediction of hematoma development was 0.297009650, and the sensitivity and specificity values were 87% and 87%, respectively. Conclusions We believe that evaluating and standardizing the microvascularization and elasticity of the kidney parenchyma before a percutaneous kidney biopsy will be potentially useful as a guiding method in the prediction of postbiopsy hemorrhage development.

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Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren""s Syndrome

Cited by 12 publications

References 22 publications

Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature

Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature

Performance Evaluation of Multiple Ultrasonographical Methods for the Detection of Primary Sjögren’s Syndrome

The Role of Superb Microvascular Imaging and Shear Wave Elastography in the Prediction of Hemorrhage Complications After Renal Parenchyma Biopsy

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