Quantitative assessment of photostability and photostabilisation of Fluvoxamine and its design for actinometry

Abstract

Wavelength-dependent forwardand reverseFluvo quantum yields have been reported.

Quantification of Unimolecular Photoreaction Kinetics: Determination of Quantum Yields and Development of Actinometers—The Photodegradation Case of Cardiovascular Drug Nisoldipine

“…International Journal of Photoenergy In any case, Φ irr NIS → PP values indicate that the UVA and the earliest section of the visible region are most efficient in NIS photodegradation. From a more general view point, our findings on the quantum yield dependence on irradiation wavelength as it has been observed for NIS, nifedipine [3], montelukast [5], fluvoxamine [6], and sunitinib [7] strongly underline the necessity of using monochromatic light for the determination of reliable values of quantum yields.…”

“…and irr NIS for data collected for both TRZ and QY various concentrations (Table 3) Nevertheless, no alternative actinometers have thus far been proposed. In this respect, the equations for Φ-order kinetics have enabled the development of new AB(1Φ) actinometers including conventional drug molecules [2,3,[5][6][7]. Accordingly, the usefulness of NIS for actinometry was established by selecting four ( = 4) irradiation wavelengths (320, 345, 370, and 390 nm) within the region of fast photodegradation.…”

“…Overall, because our approach is easy-to-implement (especially through the treatment using the initial velocity), it may represent an interesting method for the development of additional new drug-actinometers. In fact, it has thus far allowed us to propose four new accurate actinometers covering the whole spectrum of light, namely, NIS (320-400 nm), nifedipine (280-400 nm) [3], montelukast (258-380 nm) [5], fluvoxamine (260-290 nm) [6], sunitinib (320-480) [7], and 1,2-bis [2-methylbenzo[b] thiophen-3,3,4,4,5,5-hexafluoro-1-cyclopentene, DAE, for the visible 405-570 nm region [2].…”

“…irr also appears to be an important factor that reflects the rate of a particular photoreaction [6]. It can be compared between different studies using the same molecule at the same initial concentrations.…”

“…Φ-order kinetics is a recently developed approach useful for the investigation and characterisation of unimolecular and reversible photodegradation reactions of drugs [1][2][3][4][5][6][7]. It has been proven to be more suitable for the description of drugs' photoreactivity than the classical treatments based on zeroth, first, and second reaction orders [1][2][3][4].…”