“…The overall mortality rate for CM in children is 15-25%, with a recent MRI study showing that brain swelling is strongly associated with fatal outcome in CM . What is clear is that the pathogenesis is multifactorial, with a role for the immune response to the Plasmodium infection (Hunt & Grau, 2003;Ioannidis et al, 2014;Dieye et al, 2016;Mandala et al, 2017;Wolf et al, 2017) and obstruction of the microvasculature by sequestration and rosetting (Rowe et al, 2009;Craig et al, 2012;Ponsford et al, 2012;White et al, 2013;Milner et al, 2015), leading to endothelial dysfunction. What is clear is that the pathogenesis is multifactorial, with a role for the immune response to the Plasmodium infection (Hunt & Grau, 2003;Ioannidis et al, 2014;Dieye et al, 2016;Mandala et al, 2017;Wolf et al, 2017) and obstruction of the microvasculature by sequestration and rosetting (Rowe et al, 2009;Craig et al, 2012;Ponsford et al, 2012;White et al, 2013;Milner et al, 2015), leading to endothelial dysfunction.…”