Quantitative assessment of intrathoracic airway collapse in infants and children with tracheobronchomalacia

To design and test a bench model of an intraluminal optical device capable of accurately measuring airway diameter. Design: A fresh porcine trachea divided longitudinally and affixed to a linear translation stage was used to simulate 20 tracheal diameters (18.3-30.3 mm). Tungsten-halogen light was dispersed across the luminal surface by a diffraction grating. Determination of the wavelength of diffusely reflected light of peak intensity by spectrograph analysis then allowed for the calculation of an optical distance for each simulated tracheal diameter. The criterion standard was the distance as measured by the micrometer on the translation stage. Intraclass correlation (ICC) and Bland-Altman regression analysis (BARA) were performed between the optical and micrometer measurements. Subject: Trachea from a newly exsanguinated pig. Results: The ICC showed high correlation (0.994; 95% confidence interval [CI], 0.9860.998) (PϽ.001); BARA showed a small mean difference between the optical and micrometer measurements (0.052 mm; 95% CI, −0.867 to 0.762 mm) and no significant trend in bias for varying diameters (r=0.581; 95% CI, 0.187-0.814) (P=.07). Conclusions: The determination of airway diameter by means of the reflection of nonionizing radiation from the luminal surface correlates closely to actual diameter as measured by a micrometer. This bench model may be used to develop a fiberoptic intraluminal probe capable of accurately profiling airway luminal diameter and shape during flexible or rigid bronchoscopy.

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Airway Luminal Diameter and Shape Measurement by Means of an Intraluminal Fiberoptic Probe

Jowett

Weersink²,

Zhang³

et al. 2008

Arch Otolaryngol Head Neck Surg

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Pediatric bronchoscopy

Nicolaï¹

2001

Pediatr. Pulmonol.

105

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Morphometric bronchoscopy in adults with central airway obstruction: Case illustrations and review of the literature

Murgu

Colt

2009

The Laryngoscope

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The severity of airway narrowing impacts ventilatory function, quality of life, and choice of therapy for patients with central airway obstruction. The quantification of airway caliber remains a subjective estimate that depends on patient positioning, technique, and operator experience. In this article, we describe how morphometric bronchoscopy, a software processing method whereby bronchoscopic digital images are analyzed in order to measure airway lumen diameter, can be used to objectively quantify the degree of airway narrowing in adult patients with central airway obstruction.

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Quantitative assessment of intrathoracic airway collapse in infants and children with tracheobronchomalacia

Cited by 47 publications

References 13 publications

Airway Luminal Diameter and Shape Measurement by Means of an Intraluminal Fiberoptic Probe

Airway Luminal Diameter and Shape Measurement by Means of an Intraluminal Fiberoptic Probe

Pediatric bronchoscopy

Morphometric bronchoscopy in adults with central airway obstruction: Case illustrations and review of the literature

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