Quantitative assessment of expression of cell adhesion molecule (CD44) splice variants: CD44 standard (CD44s) and v5, v6 isoforms in oral leukoplakias: An immunohistochemical study

Godge, Pournima; Poonja, Leena S

doi:10.4103/0970-9290.87080

Cited by 15 publications

(15 citation statements)

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“…Moreover, a significant difference was observed in the expression patterns of CD44v6, SYNE1, and miR34a in leukoplakia patients compared to their healthy counterparts, thereby suggestive of the role of these markers in early diagnosis and early risk prediction of OSCC using non‐invasive techniques. Our findings are in concordance with the results of Godge et al; however, they are in sharp contradiction with the work of Chaiyarit et al who found a significant reduction in the expression of CD44v6 in oral leukoplakia patients compared to controls. This discrepancy could be attributed to the difference in sample source and techniques employed.…”

Section: Discussionsupporting

confidence: 73%

Uncovering the potential of CD44v/SYNE1/miR34a axis in salivary fluids of oral cancer patients

Shah

Patel

Modi

et al. 2018

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 73%

Uncovering the potential of CD44v/SYNE1/miR34a axis in salivary fluids of oral cancer patients

Shah

Patel

Modi

et al. 2018

J Oral Pathology Medicine

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“…87 In OL, CD44 variant isoform v6 (CD44 v6), but not CD44 standard or CD44 v5, was found to be decreased along with increasing grades of dysplasia. 88 However, Rautava et al 89 reported that CD44 v6 expression did not show a significant correlation with oral dysplasia and its outcome, thus reducing its potential usefulness as a prognostic marker of PPOELs.…”

Section: Cell Adhesion-related Moleculesmentioning

confidence: 99%

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

Nikitakis

Pentenero

Georgaki

et al. 2018

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.

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“…The CD44 gene represents an interesting example of SAM68-mediated coupling between signal transduction cascades and alternative splicing. CD44 pre-mRNA is affected by complex alternative splicing events occurring in 10 adjacent exons (v1–v10) to produce multifunctional transmembrane glycoprotein isoforms implicated in cell-cell and cell-matrix adhesion, migration, and invasion [ 77 ] and with crucial roles in cancer progression and metastasis [ 78 ]. By binding to A/U-rich enhancer element located within exon v5 , SAM68 promotes the production of the oncogenic CD44v5 variant ( Figure 3(b) , (A)) [ 71 ], which is upregulated in several cancers [ 78 , 79 ] and bears prognostic value in gastric and renal carcinoma [ 80 – 82 ].…”

Section: Sam68-regulated Alternative Splicing Events In Cancermentioning

confidence: 99%

SAM68: Signal Transduction and RNA Metabolism in Human Cancer

Frisone

Pradella

Matteo

et al. 2015

BioMed Research International

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Alterations in expression and/or activity of splicing factors as well as mutations in cis-acting splicing regulatory sequences contribute to cancer phenotypes. Genome-wide studies have revealed more than 15,000 tumor-associated splice variants derived from genes involved in almost every aspect of cancer cell biology, including proliferation, differentiation, cell cycle control, metabolism, apoptosis, motility, invasion, and angiogenesis. In the past decades, several RNA binding proteins (RBPs) have been implicated in tumorigenesis. SAM68 (SRC associated in mitosis of 68 kDa) belongs to the STAR (signal transduction and activation of RNA metabolism) family of RBPs. SAM68 is involved in several steps of mRNA metabolism, from transcription to alternative splicing and then to nuclear export. Moreover, SAM68 participates in signaling pathways associated with cell response to stimuli, cell cycle transitions, and viral infections. Recent evidence has linked this RBP to the onset and progression of different tumors, highlighting misregulation of SAM68-regulated splicing events as a key step in neoplastic transformation and tumor progression. Here we review recent studies on the role of SAM68 in splicing regulation and we discuss its contribution to aberrant pre-mRNA processing in cancer.

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Quantitative assessment of expression of cell adhesion molecule (CD44) splice variants: CD44 standard (CD44s) and v5, v6 isoforms in oral leukoplakias: An immunohistochemical study

Abstract: Among CD44s and its variant isoforms,v5, v6, in this study, variant isoform v6 may serve as a marker in detecting high-risk leukoplakias.

Cited by 15 publications

References 0 publications

Uncovering the potential of CD44v/SYNE1/miR34a axis in salivary fluids of oral cancer patients

Uncovering the potential of CD44v/SYNE1/miR34a axis in salivary fluids of oral cancer patients

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

SAM68: Signal Transduction and RNA Metabolism in Human Cancer

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