Quantitative Aspects of Intracellularly-Targeted Drug Delivery

How active ingredient localisation in plant tissues determines the targeted pest spectrum of different chemistries

“…The situation is very different in medical research. Intracellular targeting is seen as an emerging and promising tool in drug design . The feasibility of predicting intracellular localisation of chemicals is expected to lead ‘Toward a new age of cellular pharmacokinetics in drug discovery’ .…”

“…The feasibility of predicting intracellular localisation of chemicals is expected to lead ‘Toward a new age of cellular pharmacokinetics in drug discovery’ . It is expected that ‘intracellularly targeted drug delivery approaches will be the focus of intensive research during the next decade’, and that ‘Mathematical modeling approaches will be of great importance to determine the barriers and limiting factors in intracellular drug delivery’ . Silver sees the dynamic cell model as ‘an excellent starting point for further analysis of the uptake of ionizable antibacterials’, and Alaskosela et al see this model as ‘an important step forward in the analysis of subcellular drug distribution’.…”

“…Intracellular targeting is seen as an emerging and promising tool in drug design. 47,48 The feasibility of predicting intracellular localisation of chemicals is expected to lead 'Toward a new age of cellular pharmacokinetics in drug discovery'. 48 It is expected that 'intracellularly targeted drug delivery approaches will be the focus of intensive research during the next decade', and that 'Mathematical modeling approaches will be of great importance to determine the barriers and limiting factors in intracellular drug delivery'.…”

“…48 It is expected that 'intracellularly targeted drug delivery approaches will be the focus of intensive research during the next decade', and that 'Mathematical modeling approaches will be of great importance to determine the barriers and limiting factors in intracellular drug delivery'. 47 Silver 49 sees the dynamic cell model as 'an excellent starting point for further analysis of the uptake of ionizable antibacterials', and Alaskosela et al 50 see this model as 'an important step forward in the analysis of subcellular drug distribution'. Either the medical scientists are generally more euphoric, or the value gain from IL prediction in medical science is really high.…”

A New Frontier for Nanoparticulate Drug Delivery Systems to Improve Drug Targeting and Molecular Pharmacotherapy: Subcellul ar Bioavailability.

“…the drug intracellular distribution, can be done using fluorescence based (confocal microscopy), Raman microspectroscopy and biochemical approaches. Therapeutic delivery of micromolecular drugs or macromolecular (siRNA) by in vitro studies, laboratory animals studies for therapeutic targeting, local delivery of drug loaded DDS by nanoparticulate vectors or some clinical studies were recently published [1][2][3][4][5][6][7]. Achieving such a goal is possible by giving some physicochemical properties for DDS able to overcome the physiological and intracellular barriers, by providing the desired bioavailability of the bioactive drug, its intracellular pharmacokinetics and its desired biological or pharmacological effect.…”