Quantitative Antithrombin Deficiency Manifesting as Cerebral Sinus Thrombosis in a Patient With a Family History of Clinically Variable Venous Thromboembolic Events: A Case Report
Abstract:Antithrombin (AT III) is a potent inactivator of thrombin and factor Xa and plays a major role in the inhibition of coagulation. Inherited deficiencies of AT III are rare and pose a risk of developing venous thromboembolic disease. They can be subdivided into type I (quantitative) or type II (qualitative). Mild AT III deficiency is associated with a 2.4- to 3.5-fold risk of venous thromboembolism (VTE). Thrombosis in patients with AT III deficiency predominantly manifests as a deep vein thrombosis and may subs… Show more
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