Quantitative and Qualitative Variation in the Secretion of Protein by the Porcine Uterus during the Estrous Cycle12

Murray, Finnie A.; Bazer, Fuller W.; Wallace, H. D.; Warnick, A. C.

doi:10.1093/biolreprod/7.3.314

Cited by 125 publications

(40 citation statements)

References 22 publications

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“…Only 2 sows were available to test Treatment 6; litters of 14 and 15 were produced. Progesterone and oestrogen regulate the production and secretion of specific uterine proteins in the pig which may be related to blastocyst development (Murray, Bazer, Wallace & Warnick, 1972;Chen, Bazer, Cetorelli, Pollard & Roberts, 1973 ;Knight, Bazer & Wallace, 1973). In the present study steroid administration increased litter size only when initiated at least 14 days after oestrus and mating, a time similar to that reported when specific fractions and maximum production of uterine proteins occur in the cyclic gilt (Murray et ai, 1972).…”

supporting

confidence: 84%

Effect of administration of progesterone and oestrogen on litter size in pigs

Wildt¹,

Culver²,

Morcom³

et al. 1976

Reproduction

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Summary. Progesterone and oestrone alone or in combination were administered to sows during early gestation. A dose of 25 mg progesterone and 12\m=.\5 \g=m\g oestrone injected together for 10,5 or 2 consecutive days during the implantation interval caused increased litter size at term.The effect of exogenous steroid hormones on embryonic survival in the pig is unclear. While pro¬ gesterone given alone during gestation has no, or even a detrimental effect on embryo viability (Sammelwitz, Dziuk & Nalbandov, 1956;Haines, Warnick, Wallace & Edwards, 1957;Spies, Zimmerman, Self & Casida, 1959), the administration of progesterone and oestrogen has been re¬ ported to increase embryo survival (Reddy, Mayer & Lasley, 1958;Day, Romack & Lasley, 1963 Progesterone (A*-pregnen-3,20-dione: Sigma Chemical Co.) and oestrone (A1,3,5(10)-estratrien-3-ol-17-one: Sigma Chemical Co.) solutions were prepared as described by Reddy et al. (1958) and injected i.m. in volumes of 2 or 4 ml at invervals of 23-25 hr. The control and hormone treatments used are shown in Table 1. Control animals received cottonseed oil at corresponding times of treat¬ ment administration, but because there were no differences in mean litter size in the various subgroups, these results were pooled into one control group (Group 0).The number ofsows returning to oestrus, the number carrying the litter to term and the total number of pigs farrowed were recorded. Mean litter size was calculated and statistically tested by least squares regression analysis (Harvey, 1960).Conception rate was high in all treated sows and did not differ from that in controls. There was no effect of breed of sow or individual boar on litter size results (least squares regression analysis). As shown in Table 1, there was a significant increase in litter size when progesterone and oestrone were administered from Days 14-23 (Group 2), a period during which implantation is occurring (Green & Winters, 1946). Administration of both steroids for shorter intervals at this time resulted in increased litter size only in Groups 4 and 6. There was no effect of treatment on the number of pigs stillborn.

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supporting

confidence: 84%

Effect of administration of progesterone and oestrogen on litter size in pigs

Wildt¹,

Culver²,

Morcom³

et al. 1976

Reproduction

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“…Changes in uterine components during early pregnancy and the oestrous cycle have been observed in other species including the rabbit (Daniel, 1968), pig (Murray, Bazer, Wallace & Warnick, 1972), and man (Shirai, Iizuka & Notake, 1972). A steroid-binding function has been suggested for the progesterone-dependent rabbit protein, uteroglobin (Arthur, Cowan & Daniel, 1972;Fowler, Johnson, Walters & Pratt, 1976), but the function of the other uterine proteins and their possible roles in maintaining the development of the embryos remain obscure.…”

Section: Discussionmentioning

confidence: 80%

Uterine proteins and the activation of embryos from mice during delayed implantation

Pratt¹

1977

Reproduction

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Summary. Ovariectomy-induced delay of implantation was used to study the role of the uterine environment in controlling implantation in mice. Labelling studies in vivo showed that uterine protein synthesis and secretion is maximal 2\p=n-\5h and 24\p=n-\30h after the oestradiol injection which initiates implantation. Embryos removed from uteri 5,12 or 30 h after oestradiol injection were able to transport and utilize precursors of nucleic acids and proteins in short-term cultures at the same rate as normal embryos, although 'delayed' embryos had low levels of activity. These results suggest that 'delayed' embryos are metabolically activated within 5 h of release from delay, perhaps because of the hormonally-induced changes in uterine proteins which occur at this time.

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“…Conceptus material was obtained at hysterectomy (Murray, Bazer, Wallace & Warnick, 1972). Conceptuses were flushed from the uterine horns using sterile saline (Zavy, Bazer, Thatcher & Wilcox, 1980).…”

Section: Methodsmentioning

confidence: 99%