Quantitative and Qualitative Characterization of Phagocytic Activity of Macrophages of Bone Marrow and Fetal Origin

Lokhonina, Anastasia; Макаров, А. В.; Elchaninov, Andrey; Arutyunyan, I. V.; Шмакова, Т. В.; Grinberg, Maria; Usman, Natalia; Surovtsev, Viktor; Chernikov, Valery P.; Fatkhudinov, Timur

doi:10.1007/s10517-019-04481-5

Cited by 4 publications

(3 citation statements)

References 11 publications

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“… [58] , [59] , [60] As will be discussed below, the efferocytic capabilities of resident KCs and recruited MoMΦs can differ. 61 In the past decade, single-cell RNA sequencing has revealed hepatic macrophage heterogeneity in mouse models as well as humans. 62 For example, two functionally different subsets of murine KCs, a major CD206 low ESAM – population (KC1) and a minor CD206 hi ESAM + population (KC2), were identified in both the steady-state and in diet-induced obesity.…”

Section: Hepatic Macrophage Heterogeneity In Liver Diseasementioning

confidence: 99%

Efferocytosis in liver disease

Shi,

Moore,

Wang

et al. 2024

JHEP Reports

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Section: Hepatic Macrophage Heterogeneity In Liver Diseasementioning

confidence: 99%

Efferocytosis in liver disease

Shi,

Moore,

Wang

et al. 2024

JHEP Reports

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“…The monocyte-derived macrophages which colonize the liver in the aftermath of KC depletion provide more efficient clearance of Neisseria meningitidis or Listeria monocytogenes by phagocytosis compared with KCs [ 81 ]; they also exert a more pronounced pro-inflammatory effect [ 76 ]. Our own in vitro experiments have demonstrated that, at early time points of stimulation, monocytic macrophages engulf latex particles at higher rates compared with KCs [ 87 , 120 ]. Such data can be interpreted in terms of hepatic tissue macrophage niche and its special features.…”

Section: The Concept Of Macrophage Niche and Its Application To Kcsmentioning

confidence: 99%

An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche

Elchaninov

Vishnyakova

Menyailo

et al. 2022

IJMS

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Macrophages are key participants in the maintenance of tissue homeostasis under normal and pathological conditions, and implement a rich diversity of functions. The largest population of resident tissue macrophages is found in the liver. Hepatic macrophages, termed Kupffer cells, are involved in the regulation of multiple liver functionalities. Specific differentiation profiles and functional activities of tissue macrophages have been attributed to the shaping role of the so-called tissue niche microenvironments. The fundamental macrophage niche concept was lately shaken by a flood of new data, leading to a revision and substantial update of the concept, which constitutes the main focus of this review. The macrophage community discusses contemporary evidence on the developmental origins of resident macrophages, notably Kupffer cells and the issues of heterogeneity of the hepatic macrophage populations, as well as the roles of proliferation, cell death and migration processes in the maintenance of macrophage populations of the liver. Special consideration is given to interactions of Kupffer cells with other local cell lineages, including Ito cells, sinusoidal endothelium and hepatocytes, which participate in the maintenance of their phenotypical and functional identity.

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“…At the same time, non-activated monocytic macrophages exhibit a constant level of endocytosis, while in Kupffer cells a sharp burst of phagocytic activity detected at the initial stages of the experiment is followed by a rapid decline. It is interesting to note that the addition of M1 or M2 polarization factors to the culture medium upregulates phagocytic activity in both types of macrophages [66,94].…”

Section: The Plasticity Of Macrophagesmentioning

confidence: 99%

Phenotypical and Functional Polymorphism of Liver Resident Macrophages

Elchaninov

Fatkhudinov

Vishnyakova

et al. 2019

Cells

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Liver diseases are one of the main causes of mortality. In this regard, the development of new ways of reparative processes stimulation is relevant. Macrophages play a leading role in the regulation of liver homeostasis in physiological conditions and in pathology. In this regard, the development of new liver treatment methods is impossible without taking into account this cell population. Resident macrophages of the liver, Kupffer cells, represent a unique cell population, first of all, due to their development. Most of the liver macrophages belong to the self-sustaining macrophage cell population, whose origin is not bone marrow. In addition, Kupffer cells are involved in such processes as regulation of hepatocyte proliferation and apoptosis, remodeling of the intercellular matrix, lipid metabolism, protective function, etc. Such a broad spectrum of liver macrophage functions indicates their high functional plasticity. The review summarizes recent data on the development, phenotypic and functional plasticity, and participation in the reparative processes of liver macrophages: resident macrophages (Kupffer cells) and bone marrow-derived macrophages.

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Quantitative and Qualitative Characterization of Phagocytic Activity of Macrophages of Bone Marrow and Fetal Origin

Cited by 4 publications

References 11 publications

Efferocytosis in liver disease

Efferocytosis in liver disease

An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche

Phenotypical and Functional Polymorphism of Liver Resident Macrophages

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