Quantitative and qualitative changes in the mitochondria in hepatocytes during postnatal development of male rats

David, Heinz

doi:10.1016/s0014-4908(79)80053-8

Cited by 13 publications

(15 citation statements)

References 21 publications

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“…In agreement with this result is a previous study showing that proliferation of mitochondria reached a maximum value at 180 days of age. 32 In addition, due to the increased mitochondrial protein mass, NAD-linked oxidative capacities signi®cantly increased in 180-day-old rats compared with younger animals. Taken together the above results indicate that liver cells from 180-day-old rats exhibit similar mitochondrial oxidative capacities to those found in younger animals, or even better.…”

Section: Discussionmentioning

confidence: 99%

Oxidative activity in mitochondria isolated from rat liver at different stages of development

Iossa

Lionetti

Mollica

et al. 1998

Cell Biochem. Funct.

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The purpose of this study was to evaluate the oxidative capacities in hepatic mitochondria isolated from prepubertal, young adult and adult rats (40, 90 and 180 days of age, respectively). In these rats, mitochondrial respiratory rates using FAD- and NAD-linked substrates as well as mitochondrial protein mass were measured. The results show that only the oxidative capacity of FAD-linked pathways significantly declined in mitochondria from 180-day-old rats compared with those from younger animals. When we consider FAD-linked respiration expressed per g liver, no significant difference was found among rats of different ages because of an increased mitochondrial protein mass found in 180-day-old rats. However, when FAD-linked and lipid-dependent respiratory rates were expressed per 100 g body weight, significant decreases occurred in 180-day-old rats. Therefore, the decrease in liver weight expressed per 100 g body weight rather than an impaired hepatic cellular activity may be the cause of body energy deficit in 180-day-old rats.

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Section: Discussionmentioning

confidence: 99%

Oxidative activity in mitochondria isolated from rat liver at different stages of development

Iossa

Lionetti

Mollica

et al. 1998

Cell Biochem. Funct.

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“…Quantitative changes of complex IV activity during fetal and postnatal development were attributed to mitochondria1 proliferation, to the role of adenine nucleotides, and to translational regulation of mitochondria1 differentiation [2,5,6,401. Complex-IV-specific activity was reported to be about 2-6-fold higher in the adult state than in the fetal state in various species [19,411.…”

Section: Discussionmentioning

confidence: 99%

“…Tissue-specific proliferation of mitochondria [2], mitochondrial maturation by a net uptake of adenine nucleotides [3, 41 and a developmental-specific expression of key enzymes [5,61 were found to contribute to the postnatal increase in mitochondrial ATP production. Cytochrome-c oxidase (complex IV), comprising three large catalytic subunits and ten smaller polypeptides, was studied most intensively : isoforms of subunits VIa, VIIa and VIII were found in various mammalian tissues and a regulation of the rate of oxidative phosphorylation by expressing different isoforms seemed possible .…”

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confidence: 99%

Cytochrome-c Oxidase in Developing Rat Heart Enzymic Properties and Amino-terminal Sequences Suggest Identity of the Fetal Heart and the Adult Liver Isoform

et al. 1995

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“…However, Lang and Herbener (1972) observed that the volume density is greater in weanling rats than in newborn animals, and there is no difference in the length and diameter between animals of the two age groups. David (1979) reported that the volume density increases during postnatal development. The reason for these disagreements is probably that no distinction was made between periportal and perihepatic hepatocytes in these reported studies.…”

Section: Discussionmentioning

confidence: 99%

“…However, there have been no reports in the literature that answer this question, except for our paper on postnatal development of the volume density (Asada-Kubota et al., 1982). Papers describing the quantitative morphology of the hepatocyte mitochondrion during postnatal development have been published (Rohr et al, 1971;Lange and Herbener, 1972;Herzfeld et al, 1973;David, 1979). In these papers, however, measurements were carried out without distinction between periportal and perihepatic hepatocytes, i.e., on the assumption that all hepatocytes are identical.…”

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confidence: 99%

Development of morphologic heterogeneity of hepatocyte mitochondria in the mouse

et al. 1984

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The ultrastructure of mitochondria in periportal and perihepatic hepatocytes from newborn, 5-, 10-, and 20-day-old, and adult male ddY mice was analyzed by quantitative electron microscopy. In newborn and 5- and 10-day-old animals, the axial ratio (length per diameter), surface to volume ratio (area of the outer membrane per unit mitochondrial volume), and volume density were not significantly different between periportal and perihepatic cells. In 20-day-old and adult animals, the surface to volume ratio was greater in perihepatic cells than periportal cells, and the volume density was greater in periportal cells than perihepatic cells. The axial ratio became greater in perihepatic cells than periportal cells in adult animals. However, there were no differences in the surface density of the outer membrane, and of the inner membrane and cristae between the cells of both zones in all age groups examined. When the data were expressed as volume and area per cell, the patterns of subacinar distribution and age-related changes differed from the patterns seen in the volume and surface density data mainly in adult animals. This difference was generally caused by the marked increase in hepatocyte volume between 20 days of age and adulthood, especially in perihepatic cells. The results show that differences between mitochondria in periportal cells and those in perihepatic cells in the shape (the axial and surface to volume ratios), volume density, and area of the outer membrane per cell, evident in adult animals, are not present in newborn animals but arise during postnatal development.

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Quantitative and qualitative changes in the mitochondria in hepatocytes during postnatal development of male rats

Cited by 13 publications

References 21 publications

Oxidative activity in mitochondria isolated from rat liver at different stages of development

Oxidative activity in mitochondria isolated from rat liver at different stages of development

Cytochrome-c Oxidase in Developing Rat Heart Enzymic Properties and Amino-terminal Sequences Suggest Identity of the Fetal Heart and the Adult Liver Isoform

Development of morphologic heterogeneity of hepatocyte mitochondria in the mouse

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