Quantitative and Qualitative Analysis of Some Inorganic Compounds by Raman Spectroscopy

Abstract

Raman spectra have been measured for a number of nitrates, nitrites, sulfates, ferrocyanides, and ferricyanides, both in the solid phase and in aqueous solution. Accurate locations of peak maxima are given. Limits of detection for some of the compounds are given for solutions and for solid mixtures in NaNO3. Preliminary measurements have been made on core material recovered from the storage tanks on the Hanford site in Richland, Washington. Representative spectra are presented, showing that it is possible to observe responses of individual components from measurements made directly on untreated cores, with the use of a fiberoptic sampling probe.

Detecting and Identifying the Complexation of Nimodipine with Hydroxypropyl-β-Cyclodextrin Present in Tablets by Raman Spectroscopy

“…Thermal analysis (DSC, TG), solid-state 13 C NMR, infrared spectroscopy (IR) and powder X-ray diffractometry (XRD) have been frequently employed for the inclusion confirmation in the solid state. 11 However, the determination of drug/ CDs complexation formation in the solid dosage form is more difficult, particularly when the drug is present as a low percentage of the total mass.…”

“…It has been used for the identification of active substances in pharmaceuticals, 12 their qualitative 13 and quantitative analysis, 14 the characterization of different crystalline forms 15,16 and even for online monitoring of the pharmaceutical blending process. 17 Raman spectroscopy has offered several advantages over other analytical technologies.…”

Quantitative analysis using Raman spectroscopy without spectral standardization

“…In fact, there have been relatively few publications containing actual detection limits for the types of samples discussed in this paper. 3,4,13 In order to characterize the sensitivity of the Raman spectrometer, and to provide a measure of the expected detection limits from a similar instrument, two studies were performed. Low-concentration samples of benzene were made using water and CCl 4 as solvents.…”

Use of organic functional group concentrations as a means of screening for energetics

“…Other reports by Westinghouse Hanford Company addressed the issues of importance for potential deployment of Raman Spectroscopy for in-tank characterization or for hot-cell applications (Crawford et al 1994;Lombardi et al 1994;Lopez et al 1995;Phillip 1994).…”