Quantitative and qualitative analysis of proteins in fresh frozen plasma obtained from whole blood donations and prepared with two photochemical treatments

Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation

“…We were able to confirm that the activities of most plasma coagulation factors and antithrombotic proteins were affected, but only moderately, by the IBS procedure. Only FVII and FVIII displayed a somewhat lower degree of retention of their initial pre‐IBS activity (67%), in accordance with previous studies . For all factors, the values were well within the reference ranges and met the requirements of the Guide to the Preparation, Use and Quality Assurance of Blood Components published by the Directorate for the Quality of Medicine and Health Care of the Council of Europe (EDQM) .…”

Paired analysis of plasma proteins and coagulant capacity after treatment with three methods of pathogen reduction

“…A direct comparison of plasma quality after MB and AS treatment was done in two previous studies, both using a pool‐and‐split design with 12 replicate tests . Whereas Osselaer and coworkers report a generally stronger degrading effect of MB than AS, this was not the case in our study.…”

“…Only the FV and FXI results were uniformly more favorable for AS treatment. Cid and colleagues found no significant differences in their smaller set of comparisons.…”

Paired comparison of methylene blue‐ and amotosalen‐treated plasma and cryoprecipitate

“…The loss of coagulation factors seen in FFP following PI treatment is well documented by several authors . The design of our study allowed the direct comparison of two PI methods, as well as accounting for dilution factors and volume losses.…”