Quantitative and Diffusion MR Imaging as a New Method To Assess Osteoporosis

Hatipoğlu, Hatice Gül; Selvi, Ahmet; Cılız, Deniz; Yüksel, Enis

doi:10.3174/ajnr.a0704

Cited by 57 publications

(47 citation statements)

References 19 publications

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“…The perfusion process is thus responsible of an overestimation of MD [22,47]. In this regard, our MD values are lower than those previously reported [17,[22][23][24].…”

Section: Discussioncontrasting

confidence: 55%

“…Unlike the contradictory results obtained in vertebral cancellous bone [17,[22][23][24], a clear relationship between MD and T-score was found in the femoral neck. These differences between our MD results and those obtained in vertebrae, are due to a slower water dynamic investigated in this study compared to that in vertebral bone [17,[22][23][24].…”

Section: Discussionmentioning

confidence: 38%

“…Because the results discussed here highlight a strong correlation between FA and T-score, they underline the greatest potential of a DTI rather than a DWI approach [17,[22][23][24]46], to assess osteoporosis in cancellous bone.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, since the amount of bone-marrow water compared to bone-marrow fat is higher in vertebrae than in the femoral neck, water dynamic in the femoral neck is more restricted than in vertebrae. As a consequence, to optimize the measurements of water with a slower dynamic, higher b-values compared to those employed to perform DWI in vertebrae [17,[22][23][24]45,46] were used. In this work, by selecting b = 2500 s/mm 2 , we measured an averaged MD approximately equal to 3 * 10 −4 s/mm 2 in the femoral neck.…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion weighted imaging (DWI) has also been used to investigate vertebral bone although so far it has failed to show a clear relationship between apparent diffusion coefficient (ADC) and BMD [17,[22][23][24]. A more accurate investigation of trabecular bone architecture than that provided by DWI could potentially be found with diffusion tensor imaging (DTI) methods [25] as recently suggested in in vitro investigations [26].…”

Section: Introductionmentioning

confidence: 99%

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Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: Preliminary experience

Manenti

Capuani

Fanucci

et al. 2013

Bone

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H-MRS)Bone marrow fat fraction (FF) Femur Osteoporosis Fractional anisotropy (FA) We assessed the potential of diffusion tensor imaging (DTI) in combination with proton magnetic resonance spectroscopy ( 1 H-MRS), in cancellous bone quality evaluation of the femoral neck in postmenopausal women. Introduction: DTI allows for non-invasive microarchitectural characterization of heterogeneous tissue. In this work we hypothesized that DTI parameters mean diffusivity (MD) and fractional anisotropy (FA) of bone marrow water, can provide information about microstructural changes that occur with the development of osteoporosis disease. Because osteoporosis is associated with increased bone marrow fat content, which in principal can alter DTI parameters, the goal of this study was to examine the potential of MD and FA, in combination with bone marrow fat fraction (FF), to discriminate between healthy, osteopenic and osteoporotic subjects, classified according to DXA criteria. Materials and methods: Forty postmenopausal women (mean age, 68.7 years; range 52-81 years), underwent a Dual-energy X-ray absorptiometry (DXA) examination in femoral neck, to be classified as healthy (n = 12), osteopenic (n = 14) and osteoporotic (n = 14) subjects. ) of femoral neck were obtained in each subject at 3T. The study protocol was approved by local Ethics Committee. MD, FA, FF and MD/FF, FA/FF were obtained and compared among the three bone-density groups. One-way ANOVA with multiple comparisons Bonferroni test and Pearson correlation analysis were applied. Receiver operating characteristic (ROC) curve analysis was also performed. Results: Reproducibility of DTI measures was satisfactory. CV was approximately 2%-3% for MD and 4%-5% for FA measurements. Moreover, no significant difference was found in both MD and FA measurements between two separate sessions (median 34 days apart) comprised of six healthy volunteers. FF was able to discriminate between healthy and osteoporotic subjects only. Conversely MD and FA were able to discriminate healthy from osteopenic and healthy from osteoporotic subjects, but they were not able to discriminate between osteopenic and osteoporotic patients. A significant correlation between MD and FF was observed in healthy group only. A moderate correlation was found between MD and T-score when all groups together are considered. No significant correlation was found between MD and T-score within groups. A significant positive correlation between FA and FF was found in both osteopenic and osteoporotic groups. Vice-versa no correlation between FA and FF was observed in healthy group. A high significant positive correlation was found between FA and T-score in all groups together, in healthy and in osteoporotic groups. MD/FF and FA/FF are characterized by a higher sensitivity and specificity compared to MD and FA in the discrimination between healthy, and osteoporotic subjects. MD/FF vs FA/FF graph extracted from femoral neck, identify all healthy individuals according to DXA results. Conclusion: DTI-1 H-MRS proto...

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“…The perfusion process is thus responsible of an overestimation of MD [22,47]. In this regard, our MD values are lower than those previously reported [17,[22][23][24].…”

Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 38%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: Preliminary experience

Manenti

Capuani

Fanucci

et al. 2013

Bone

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Echo‐planar DWI variants: A comparative study in vertebral marrow pathology

Kesen,

Tokgöz

2024

J of Clinical Ultrasound

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PurposeSingle‐shot echo‐planar imaging (ss‐EPI) has limited application in vertebral column imaging due to numerous artifacts. Therefore, we aimed to compare readout‐segmented echo‐planar imaging (rs‐EPI) to ss‐EPI and assess its value in the differential diagnosis of vertebral infectious, tumoral infiltrative, and degenerative disorders.Materials and MethodsSixty‐six adult patients with spondylodiscitis (SD, n = 26), tumoral infiltration (TI, n = 20), or Modic type I degeneration (DE, n = 20) findings on spinal magnetic resonance imaging (MRI) included in this retrospective study. Two radiologists scored images for quality on a 4‐point scale (image resolution, degree of geometric distortion, lesion selectivity, and diagnostic reliability) and measured signal intensity (SI), apparent diffusion coefficient (ADC), signal‐to‐noise ratio (SNR), and contrast‐to‐noise ratio (CNR). DE and SD groups also united to form the benign group.ResultsIn all groups, rs‐EPI performed better than ss‐EPI in image quality, SNR, and CNR (p < .05). The difference between mean pathological ADC (ADCP) in the two sequences was statistically significant (p < .05). There was no significant difference between the groups in terms of ADCP in rs‐EPI (p = .229), unlike ss‐EPI (p = .025). Pathological SI (SIP) and CNR in rs‐EPI were significantly higher in the malignant group than benign group (p = .002, p < .001). In rs‐EPI, no significant difference was found between malignant and benign groups' ADCP (p = .13).ConclusionThe rs‐EPI is a diffusion‐weighted imaging (DWI) method with higher image quality that diminishes motion‐induced phase errors and increases resolution through phase corrections. However, the distinction of malignant and benign vertebral bone marrow pathologies is unsatisfactory for rs‐EPI compared with ss‐EPI.

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Apparent diffusion coefficient and fractional anisotropy in the vertebral bone marrow

Ueda

Miyati

Ohno

et al. 2010

Magnetic Resonance Imaging

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Purpose: To assess the state of cancellous tissue we analyzed the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in vertebral bone marrow.Materials and Methods: With 1.5 T magnetic resonance imaging (MRI), single-shot diffusion echo planar imaging was used with b factors of 0 and 1000 s/mm 2 , diffusionsensitizing gradient in six directions, sensitivity encoding technique, effective TE of 74 msec, and TR of 1800 msec. ADC and FA were determined in the lumbar vertebral body of 11 normal subjects (age 31 632-635 years), and then compared with the bone mineral density (BMD) obtained with dual-energy x-ray absorptiometry (DXA). Moreover, fat fraction (FF) of the bone marrow was measured with spectral presaturation with inversion recovery (SPIR) in the same subject.Results: A strong negative correlation was found between ADC and BMD for low or moderate FF in vertebral bone marrow. Moreover, a significant positive correlation was noted between ADC and FF in this region. There was a positive correlation between FA and BMD, and no correlation between FA and FF in the vertebral bone marrow.Conclusion: Diffusion analyses with ADC and FA make it possible to obtain more detailed information on the structure of cancellous tissue and bone metabolism.

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Quantitative and Diffusion MR Imaging as a New Method To Assess Osteoporosis

Cited by 57 publications

References 19 publications

Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: Preliminary experience

Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: Preliminary experience

Echo‐planar DWI variants: A comparative study in vertebral marrow pathology

Apparent diffusion coefficient and fractional anisotropy in the vertebral bone marrow

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