Quantitative analysis of β-adrenergic blocking agents by NMR spectroscopy

Iorio, M. A.; Farina, A.; Doldo, A.

doi:10.1016/0731-7085(87)80002-x

Cited by 21 publications

(8 citation statements)

References 8 publications

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“…These methods include: spectrophotometry [2][3][4], NMR spectroscopy [5,6], fluorometry [7,8], potentiometry [9], TLC [10,11], GC [12,13], HPLC [14][15][16][17][18], capillary electrophoresis [19,20] and electrocapillary chromatography [21][22][23]. These meth- * Tel.…”

Section: Introductionmentioning

confidence: 99%

A simple spectrophotometric method for the determination of β-blockers in dosage forms

Al-Ghannam¹

2006

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

A simple spectrophotometric method for the determination of β-blockers in dosage forms

Al-Ghannam¹

2006

Journal of Pharmaceutical and Biomedical Analysis

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“…Different temperatures were tested (25,30,35 and 40 o C) and it was found that the same results were obtained so room temperature (25 o C) was selected for determination. Temperature couldn't be increased more than 40 o C as conductometry electrode (conductivity cell) could be affected by elevated temperature.…”

Section: Effect Of Temperaturementioning

confidence: 97%

“…Several methods were used for sotalol HCl determination in pure and pharmaceutical dosage forms. These methods include spectrophotometric [25][26][27][28][29], spectrofluorimetric [30,31], HPLC [29,32], LC [33], capillary zone electrophoresis [34] and NMR spectroscopic methods [35].…”

Section: Introductionmentioning

confidence: 99%

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

et al. 2012

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A simple, precise, rapid, and low-cost conductometric method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl in pure form and in pharmaceutical formulations using silver nitrate has been described. The method is based on the precipitation of oxalate or chloride ions coming from the cited drugs with silver ions, yielding silver oxalate or silver chloride and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-15 mg. Various experimental conditions were established and results obtained showed good recoveries with relative standard deviation of 0.909, 0.955 and 0.983 for naftidrofuryl, propafenone and sotalol, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official or reference methods.Oxalate Sotalol HCl Silver nitrate Propafenone HCl Naftidrofuryl oxalate Conductometric titration

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“…[2] The methods of analysis of the bulk drugs are officially in the British Pharmacopoeia a potentiometric titration method for both drugs. [3] Several methods have been reported for the analysis of atenolol, including UV spectrophotometry, [4,5] colorimetry, [6] fluorimetry, [7] 1 HNMR, [8] IR, [9] voltammetry, [10,11] potentiometry, [12] TLC, [13,14] HPTLC/ UV detection, [15,16] GC/MS, [17] HPGC/MS, [18] HPLC/UV detection, [19,20] HPLC-tandem mass spectrometry (HPLC/MS/MS), [21,22] ultraperformance liquid chromatography with tandem mass spectrometric (UPLC/MS/MS), [23] HPLC-fluorescence detection, [24] capillary liquid chromatography (CLC) and pressurized capillary electrochromatography (pCEC), [25] CZE, [26,27] miceller electrokinetic chromatography (MEKC) [28] and FIA-UV detection. [29] Reviewing the literature revealed that up to the present time, nothing has been published concerning the chemiluminescence determination of atenolol.…”

Section: Introductionmentioning

confidence: 99%

Determination of enalapril maleate and atenolol in their pharmaceutical products and in biological fluids by flow‐injection chemiluminescence

Alarfaj¹,

Al-Abdulkareem

Aly³

2009

Luminescence

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A chemiluminescent method using flow injection (FI) was investigated for rapid and sensitive determination of enalapril maleate and atenolol, which are used in the treatment of hypertension. The method is based on the sensitizing effect of these drugs on the Ce(IV)-sulfite reaction. The different experimental parameters affecting the chemiluminescence (CL) intensity were carefully studied and incorporated into the procedure. The method permitted the determination of 0.01-3.0 microg mL(-1) of enalapril maleate in bulk form with correlation coefficient r = 0.99993, lower limit of detection (LOD) 0.0025 microg mL(-1) (S/N = 2) and lower limit of quantitation (LOQ) 0.01 microg mL(-1). The linearity range of atenolol in bulk form was 0.01-2.0 microg mL(-1) (r = 0.99989) with LOD of 0.0003 microg mL(-1) (S/N = 2) and LOQ of 0.01 microg mL(-1). In biological fluids the linearity range of enalapril maleate was 0.1-2.0 microg mL(-1) in both urine and serum, and for atenolol the linearity range was 0.1-1.0 microg mL(-1) in both urine and serum. The method was also applied to the determination of the drugs in their pharmaceutical preparations.

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Quantitative analysis of β-adrenergic blocking agents by NMR spectroscopy

Cited by 21 publications

References 8 publications

A simple spectrophotometric method for the determination of β-blockers in dosage forms

A simple spectrophotometric method for the determination of β-blockers in dosage forms

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

Determination of enalapril maleate and atenolol in their pharmaceutical products and in biological fluids by flow‐injection chemiluminescence

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