Quantitative analysis of visible surface defect risk in tablets during film coating using terahertz pulsed imaging

Niwa, Masahiro; Hiraishi, Yasuhiro

doi:10.1016/j.ijpharm.2013.11.051

Cited by 18 publications

(4 citation statements)

References 36 publications

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“…Weak interparticle bonding in the core tablets is implicated for the surface erosion phenomenon. 6 Interparticle bonding is impacted by the surface and compaction characteristics of the materials used in the tablet formulation. For example, high drug load tablets of a highly crystalline active pharmaceutical ingredient can sometimes necessitate the use of wet granulation unit operation wherein a hydrophilic polymer binder facilitates interparticle bonding.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets

Narang

Breckenridge

Guo

et al. 2017

Journal of Pharmaceutical Sciences

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Surface erosion of uncoated tablets results in processing problems such as dusting and defects during coating and is governed by the strength of particle bonding on tablet surface. In this study, the correlation between dusting tendency of tablets in a coating pan with friability and laser ablation surface hardness was assessed using tablets containing different concentrations of magnesium stearate and tartaric acid. Surface erosion propensity of different batches was evaluated by assessing their dusting tendency in the coating pan. In addition, all tablets were analyzed for crushing strength, friability, modified friability test using baffles in the friability apparatus, and weight loss after laser ablation. Tablets with similar crushing strength showed differences in their surface erosion and dusting tendency when rotated in a coating pan. These differences did not correlate well with tablet crushing strength or friability but did show reasonably good correlation with mass loss after laser ablation. These results suggest that tablet surface mass loss by laser ablation can be used as a minipiloting (small-scale) tool to assess tablet surface properties during early stages of drug product development to assess the risk of potential large-scale manufacturing issues.

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Section: Discussionmentioning

confidence: 99%

Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets

Narang

Breckenridge

Guo

et al. 2017

Journal of Pharmaceutical Sciences

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“…The results of which were successfully validated against scanning electron microscopy (SEM), XµCT, acid uptake tests and loss on drying (LOD) test, a measure of water content in sample tablets. TEFPS was previously shown to reveal information on surface density and roughness [20,21] and it was further demonstrated in [32] how TEFPS could additionally provide information on the physical strength of the tablet surface for the estimation of surface defect risk. The ability to resolve air gaps in turn could provide information on adhesion quality between core and coatings in calendered tablets [33].…”

Section: Defects Identificationmentioning

confidence: 99%

Review of Terahertz Pulsed Imaging for Pharmaceutical Film Coating Analysis

Alves-Lima

Song

et al. 2020

Sensors

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Terahertz pulsed imaging (TPI) was introduced approximately fifteen years ago and has attracted a lot of interest in the pharmaceutical industry as a fast, non-destructive modality for quantifying film coatings on pharmaceutical dosage forms. In this topical review, we look back at the use of TPI for analysing pharmaceutical film coatings, highlighting the main contributions made and outlining the key challenges ahead.

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“…THz spectroscopy can be used for non-destructive diagnosis of mechanical deformation in polymers [4]. By other researchers, the non-destructive THz imaging inspection has been applied to space-shuttle ceramic style bonded state [5], tablet surface defect analysis [6], in the medical field, non-destructive inspection of cancer cell [7].…”

Section: Terahertz Waves and Applicationsmentioning

confidence: 99%

Non-Contact Terahertz Inspection of Water Content in Concrete of Infrastructure Buildings

Tanabe¹,

Kanai²,

Kuroo³

et al. 2018

WJET

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Concrete is the most widely used for construction materials in the world. Water content of concrete is an important parameter in terms durability of concrete structures. Terahertz (THz) waves, for which concrete is a porous and absorbable material, have been studied in order to establish a new non-contact inspection technology for maintenance of concrete structures. In this study, THz transmittance and reflectance of concrete in drying process were measured with a 60 GHz GUNN diode and absorption coefficient is analyzed for concrete with various water contents. It is shown that quantitative detection below 10% is possible for the water content at surface area of concrete.

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Quantitative analysis of visible surface defect risk in tablets during film coating using terahertz pulsed imaging

Cited by 18 publications

References 36 publications

Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets

Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets

Review of Terahertz Pulsed Imaging for Pharmaceutical Film Coating Analysis

Non-Contact Terahertz Inspection of Water Content in Concrete of Infrastructure Buildings

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