Quantitative analysis of vascular parameters for micro-CT imaging of vascular networks with multi-resolution

Zhao, Fengjun; Liang, Jimin; Chen, Xueli; Liu, Junting; Chen, Dongmei; Yang, Xiang; Tian, Jie

doi:10.1007/s11517-015-1337-0

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…Four-dimensional medical ultrasound imaging technology can provide more abundant image information for clinical ultrasound diagnosis, reduce missed diagnosis of lesions, and effectively improve the quality of diagnosis. It is suitable for applications in multiple medical fields such as obstetrics and gynecology, cardiovascular and pediatrics [10].…”

Section: Computational Intelligence and Medical Imaging Technologymentioning

confidence: 99%

Method for Tracking Vascular Movement of the Elderly Based on Four-Dimensional Medical Imaging

2020

IJPHPM

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In recent years, the application of computer and artificial intelligence technology in the healthcare industry has become more and more common. With the rapid development of computational intelligence, medical imaging has realized the transformation from two-dimensional to four-dimensional. This article proposes a method to track the blood vessel movement of the elderly by using four-dimensional medical imaging technology on the problem of cardiovascular and cerebrovascular diseases in the elderly that are common in medical clinics. The aim is to accurately and robustly locate the specific position of the blood vessel from the medical image data to reduce the elderly's cardiovascular. The occurrence of various complications during surgery improves the treatment rate. This article first introduces the related knowledge of the four-dimensional medical imaging technology and the vascular movement of the elderly, and then carries out the reconstruction experiment of the four-dimensional model of blood and blood vessel wall, in order to further explore the effect of the four-dimensional medical imaging technology on the intravascular blood movement of the elderly patients with cardiovascular disease. To track and monitor the situation, this article again uses 200 patients with cardiovascular and cerebrovascular diseases admitted to our hospital from 2019 to 2020 as the experimental research objects, and took 50 volunteers who received health examinations in our hospital during the same year as experimental control subjects. Through the use of four-dimensional medical color ultrasound imaging technology to detect ECG and echocardiographic parameters of the two groups of patients, it was found that the ECG parameters of the experimental group were significantly greater than those of the control group, with significant statistical differences (P<0.05); The values of left ventricular systolic diameter and left ventricular end diastolic pressure in the electrocardiogram parameters of patients with coronary heart disease in the experimental group were significantly increased compared with the control group, while the ventricular ejection fraction and cardiac-to-mitral valve ratio were significantly decreased compared with the control group.

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Section: Computational Intelligence and Medical Imaging Technologymentioning

confidence: 99%

Method for Tracking Vascular Movement of the Elderly Based on Four-Dimensional Medical Imaging

2020

IJPHPM

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“…Animal computed tomography (CT) [6,7] and highresolution animal magnetic resonance angiography [8] are commonly used imaging techniques in animal research, which have the advantages of noncontact and no imaging depth limitation. However, they also have shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous detection of cerebral blood perfusion and cerebral edema using swept‐source optical coherence tomography

Liu

et al. 2019

Journal of Biophotonics

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The progression of ischemic cerebral edema (CE) is closely related to the level of cerebral blood perfusion (CBP) and affects each other.Simultaneous detection of CBP and CE is helpful in understanding the mechanisms of ischemic CE development. In this article, a wide field of view swept-source optical coherence tomography system was used to detect CE status and CBP levels simultaneously in middle cerebral artery occlusion rats. Images reflecting these two physiological states can be reconstructed with only one C-scan. We quantify these two physiological states into four parameters, which contain two vascular parameters (vascular displacement distance and vascular perfusion density) and two edema parameters (optical attenuation coefficient and edema area). The association between the two vascular parameters and the two edema parameters was analyzed. The results show that there is a strong linear relationship between blood flow parameters and edema parameters. This work provides a new option for CE in vivo detection, and is very likely to play an important role in the development of relevant drugs or in selection of treatment options. K E Y W O R D Scerebral blood perfusion, cerebral edema, middle cerebral artery occlusion, optical attenuation coefficient, swept-source optical coherence tomography

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“…Quantitative angiogenic vessel parameters are commonly estimated from the vessel skeleton, which provides a simple and compact representation of the angiogenic vessel. Common methods for the extraction of the skeleton, namely skeletonization, are divided into two classes: morphological thinning and distance coding [ 34 ]. Morphological thinning removes the outer layers of pixels from the vascular networks successively while maintaining connectivity [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices

et al. 2017

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Angiogenesis, the growth of new blood vessels from pre-existing vessels, is a critical step in cancer invasion. Better understanding of the angiogenic mechanisms is required to develop effective antiangiogenic therapies for cancer treatment. We culture angiogenic vessels in 3D microfluidic devices under different Sphingosin-1-phosphate (S1P) conditions and develop an automated vessel formation tracking system (AVFTS) to track the angiogenic vessel formation and extract quantitative vessel information from the experimental time-lapse phase contrast images. The proposed AVFTS first preprocesses the experimental images, then applies a distance transform and an augmented fast marching method in skeletonization, and finally implements the Hungarian method in branch tracking. When applying the AVFTS to our experimental data, we achieve 97.3% precision and 93.9% recall by comparing with the ground truth obtained from manual tracking by visual inspection. This system enables biologists to quantitatively compare the influence of different growth factors. Specifically, we conclude that the positive S1P gradient increases cell migration and vessel elongation, leading to a higher probability for branching to occur. The AVFTS is also applicable to distinguish tip and stalk cells by considering the relative cell locations in a branch. Moreover, we generate a novel type of cell lineage plot, which not only provides cell migration and proliferation histories but also demonstrates cell phenotypic changes and branch information.

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Quantitative analysis of vascular parameters for micro-CT imaging of vascular networks with multi-resolution

Cited by 10 publications

References 36 publications

Method for Tracking Vascular Movement of the Elderly Based on Four-Dimensional Medical Imaging

Method for Tracking Vascular Movement of the Elderly Based on Four-Dimensional Medical Imaging

Simultaneous detection of cerebral blood perfusion and cerebral edema using swept‐source optical coherence tomography

Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices

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