Quantitative analysis of tiropramide in human plasma by gas chromatography coupled to mass spectrometry for application to a bioequivalence test

Jhee, Ok Hwa; Jeon, Yong Cheol; Choi, Ho Sun; Lee, Min Ho; Son, Ae; Lee, Joo Won; Hong, J. W.; Kim, Yong Seok; Kang, Ju Chan; Lee, Yun Sik; Shaw, Leslie M.; Kang, Jae Seon

doi:10.1016/j.cca.2005.09.029

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…In other words, the previously reported PK parameter values of tiropramide were similar to our PK results obtained by NCA analysis. After oral administration of 100 mg of tiropramide in humans, the obtained NCA PK parameters (as previously reported values) were 2.34-6.99 h for t 1/2 , 0.66-1.6 h for T max , 77.4-111 ng/mL for C max , and 267.7-812.7 h•ng/mL for AUC [6,12,[18][19][20][21]. On the other hand, the NCA PK parameters in this study were 3.41 ± 1.99 h for t 1/2 , 1.74 ± 0.63 h for T max , 69.07 ± 59.74 ng/mL for C max , and 280.34 ± 199.96 h•ng/mL for AUC, which were similar to the previously reported values.…”

Section: Discussionsupporting

confidence: 79%

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

et al. 2020

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The purpose of this study was to perform population pharmacokinetic (PPK) analysis of tiropramide in healthy Korean subjects, as well as to investigate the possible effects of various covariates on pharmacokinetic (PK) parameters of tiropramide. Although tiropramide is commonly used in digestive system-related diseases as an antispasmodic, PPK reporting and factors affecting PKs are not clearly reported. Thus, this study for healthy subjects is very significant because it could find new covariates in patients that had not been reported before or predict PPK for patients in the clinic by establishing PPK in healthy adults. By using Phoenix NLME, PK, demographic, and genetic data (collected to explain PK diversity of tiropramide in population) analyses were performed. As a basic model, a one-compartment with first-order absorption and lag-time was established and extended to include covariates that influenced the inter-subject variability. The total protein significantly influenced the distribution volume and systemic clearance of tiropramide, but genetic factors such as ABCB1 (1236C>T, 2677G>T/A, and 3435C>T), CYP2D6 (*1 and *10), OCT2 (808G>T), and PEPT1 (1287G>C) genes did not show any significant association with PK parameters of tiropramide. The final PPK model of tiropramide was validated, and suggested that some of the PK diversity in the population could be explained. Herein, we first describe the establishment of the PPK model of tiropramide for healthy Korean subjects, which may be useful as a dosing algorithm for the diseased population.

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Section: Discussionsupporting

confidence: 79%

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

et al. 2020

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“…Literature search revealed that very few pharmacokinetic studies are published and the reported methods are based on liquid chromatography-tandem mass spectrometry [2], gas chromatography/nitrogen phosphorus detector [3,4] semi-micro HPLC using column switching [5] and gas chromatography coupled to mass spectrometry [6]. Although the reported methods are sensitive and accurate but are expensive, and labor intensive.…”

Section: Introductionmentioning

confidence: 98%

A simple sample preparation with HPLC–UV method for estimation of tiropramide from plasma: Application to bioequivalence study

Khan

Loya

Natvarlal

2007

Journal of Pharmaceutical and Biomedical Analysis

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Current literature in mass spectrometry

2007

J. Mass Spectrom.

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INSTRUMENTAL TECHNIQUES & METHODSAl-Lawati H, Watts P, Welham KJ. Efficient protein digestion with peptide separation in a micro-device interfaced to electrospray mass spectrometry. [127][128][129][130][131][132][133][134][135][136][137][138] Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002DOI:10. /jms.1070 Current literature in mass spectrometry (6 weeks journals -Search completed at 4th. Oct. 2006) In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Books, Reviews & Symposia; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author. Larsen BS, Stchur P, Szostek B, Bachmura SF, Rowand RC, Prickett KB, Korzeniowski SH, Buck RC. Method development for the determination of residual fluorotelomer raw materials and perfluorooctanoate in fluorotelomerbased products by gas chromatography and liquid chromatography mass spectrometry. ANALYSIS OF ORGANIC COMPOUNDS

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Quantitative analysis of tiropramide in human plasma by gas chromatography coupled to mass spectrometry for application to a bioequivalence test

Cited by 3 publications

References 7 publications

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

A simple sample preparation with HPLC–UV method for estimation of tiropramide from plasma: Application to bioequivalence study

Current literature in mass spectrometry

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