Quantitative analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging

Niwa, Masahiro; Hiraishi, Yasuhiro; Iwasaki, Norio; Terada, Katsuhide

doi:10.1016/j.ijpharm.2013.05.010

Cited by 28 publications

(13 citation statements)

References 35 publications

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“…This was because disintegration time variation was not assessed as the authors considered the traditional disintegration test method to be inaccurate and suggested the use of alternative disintegration methods to further strengthen the model between refractive index and the propensity for the tablet to disintegrate upon contact with aqueous solutions. This study among others 82,[110][111][112] demonstrate the use of terahertz spectroscopy for rapid at-line determinations of density-related critical quality attributes of tablets.…”

Section: Pharmaceutical Applications Of Refractive Indexmentioning

confidence: 52%

“…Potential future applications associated with refractive index and terahertz spectroscopy include not only assessment of advanced solid oral dosage forms (i.e., bilayer tablets 112 ) but also development of on-line measurement strategies. 113 A study by Niwa et al 112 evaluated the adhesion integrity between 2 layers for bilayer tablets by terahertz spectroscopy. Reflectance terahertz measurements were used to obtain interface index, which represented the magnitude of change in refractive index at the layer interface but not the actual refractive index.…”

Section: Future Directionmentioning

confidence: 99%

“…The location and size of the fractures present in multilayered tablets also affect the terahertz measurements. The study by Niwa et al 112 created a bilayer tablet system in which the major fractures occurred at the interface. However, interlayer fractures also influence the terahertz measurements and overall mechanical strength of bilayer tablets.…”

Section: Future Directionmentioning

confidence: 99%

See 2 more Smart Citations

Refractive Index Measurement of Pharmaceutical Solids: A Review of Measurement Methods and Pharmaceutical Applications

Mohan

Kato

Drennen

et al. 2019

Journal of Pharmaceutical Sciences

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Section: Pharmaceutical Applications Of Refractive Indexmentioning

confidence: 52%

Section: Future Directionmentioning

confidence: 99%

Section: Future Directionmentioning

confidence: 99%

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Refractive Index Measurement of Pharmaceutical Solids: A Review of Measurement Methods and Pharmaceutical Applications

Mohan

Kato

Drennen

et al. 2019

Journal of Pharmaceutical Sciences

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“…(x) Layer separation is a crucial defect in many bilayer tablets. TPI is used to provide a precise estimate of the layer separation risk [81]. …”

Section: Terahertz Spectroscopy -A Cutting Edge Technologymentioning

confidence: 99%

Terahertz Pulse Detection Techniques and Imaging Applications

Chen¹,

Guo²

2017

Terahertz Spectroscopy - A Cutting Edge Technology

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Recent years have witnessed successful developments of detection techniques of teraherz (THz) pulse radiation and its imaging applications such as security, medicine and environmental sensing, to name an important few. Progress of detection techniques has been made in many aspects, including detection sensitivity, real-time detection, roomtemperature operation, detection bandwidth and dynamic range, spatial (wavefront) and temporal proiles and so on. New detection techniques utilizing cuting-edge materials, sensors, systems and even novel detection mechanisms contribute to advances in teraherz pulse detection. While detection techniques continuously improve, teraherz pulsed imaging (TPI) also inds broad and intriguing applications. For instance, TPI has shown applications in nondestructive evaluation in pharmaceutics, biomedical characterization of tissues, medical diagnosis of cancers, identiication of explosive hazards and examination of art and archeology. The chapter highlights recent progress of teraherz pulse detection techniques and imaging applications.

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“…Conventional tablets are not suitable where multiple drugs are mandatory for the treatment of chronic disease conditions and the drugs used are incompatible with each other. In such situations, bilayer tablets are the most suitable dosage form to administer incompatible drugs in a single dose [3,4]. Therapeutic strategies based on bilayer tablets are more popular due to improved patient compliance because of the reduced number of dose administrations [5,6].…”

Section: Original Papersmentioning

confidence: 99%

Development of Bilayer Tablets with Modified Release of Selected Incompatible Drugs

Dhiman¹,

Awasthi²,

Sk³

et al. 2016

Polim. Med.

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Background. The oral route is considered to be the most convenient and commonly-employed route for drug delivery. When two incompatible drugs need to be administered at the same time and in a single formulation, bilayer tablets are the most appropriate dosage form to administer such incompatible drugs in a single dose. Objectives. The aim of the present investigation was to develop bilayered tablets of two incompatible drugs; telmisartan and simvastatin. Material and Methods. The bilayer tablets were prepared containing telmisartan in a conventional release layer using croscarmellose sodium as a super disintegrant and simvastatin in a slow-release layer using HPMC K15M, Carbopol 934P and PVP K 30 as matrix forming polymers. The tablets were evaluated for various physical properties, drug-excipient interactions using FTIR spectroscopy and in vitro drug release using 0.1M HCl (pH 1.2) for the first hour and phosphate buffer (pH 6.8) for the remaining period of time. The release kinetics of simvastatin from the slow release layer were evaluated using the zero order, first order, Higuchi equation and Peppas equation. Results. All the physical parameters (such as hardness, thickness, disintegration, friability and layer separation tests) were found to be satisfactory. The FTIR studies indicated the absence of interactions between the components within the individual layers, suggesting drug-excipient compatibility in all the formulations. No drug release from the slow-release layer was observed during the first hour of the dissolution study in 0.1M HCl. The release-controlling polymers had a significant effect on the release of simvastatin from the slow-release layer. Thus, the formulated bilayer tablets avoided incompatibility issues and proved the conventional release of telmisartan (85% in 45 min) and slow release of simvastatin (80% in 8 h). Conclusions. Stable and compatible bilayer tablets containing telmisartan and simvastatin were developed with better patient compliance as an alternative to existing conventional dosage forms (Polim. Med. 2016, 46, 1, 5-15).

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Quantitative analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging

Cited by 28 publications

References 35 publications

Refractive Index Measurement of Pharmaceutical Solids: A Review of Measurement Methods and Pharmaceutical Applications

Refractive Index Measurement of Pharmaceutical Solids: A Review of Measurement Methods and Pharmaceutical Applications

Terahertz Pulse Detection Techniques and Imaging Applications

Development of Bilayer Tablets with Modified Release of Selected Incompatible Drugs

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