Quantitative Analysis of the Immune Cells in the Anal Mucosa

Gervaz, E; Dauge-Geffroy, M.-C.; Sobhani, Iradj; Vissuzaine, C; Mignon, M; Benhamou, G; Potet, F

doi:10.1016/s0344-0338(11)80649-7

Cited by 13 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, a sitz bath ensures local cleanliness and decreases the local inflammatory response and vascular swelling, which ultimately produces a therapeutic effect. (Gervaz et al, 1995;Sobhani et al, 2002). S Furthermore, haemorrhoids exert major anal resting pressure causing the http://dx.doi.org/10.4314/ajtcam.v10i2.21 closure of the anus.…”

Section: Discussionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled trial of a Chinese herbal <i>Sophora</i> flower formula in patients with symptomatic haemorrhoids: A preliminary study

Man¹,

Chen²,

Wang³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Dried flowers and buds of Sophora japonica (Huaihua) are used in China, Japan and Korea for treating haematemesis and bleeding haemorrhoids. This study compared the clinical safety and efficacy of a Sophora flower formula with a placebo for the conservative treatment of symptomatic haemorrhoids. The study was a prospective, double-blind, randomized placebo-controlled trial. The clinical effective rate, symptom score and the incidence of important clinical events were used as observation indices to evaluate the effect of the Sophora flower formula. The results showed that after 7 days of treatment, improvement was observed in 87.0% of the patients' major symptoms in the Sophora flower formula group compared with 81.8% of those in the placebo group. After 14 days, 78.2% patients in the Sophora flower formula group were asymptomatic, whereas 40.9% of those in the placebo group exhibited residual symptoms. However, the difference between both groups was not statistically significant. As the bowel habits of the patients improved and as the patients took sitz baths, their symptoms improved drastically, regardless of the use of the Sophora flower formula. These findings indicate that the traditional Chinese Sophora flower formula is clinically safe; however, its effects on haemorrhoids need to be studied in a larger sample size and with different dosages. The present study results may be a potential clinical reference for physicians prescribing medications for patients with symptomatic haemorrhoids.

show abstract

Section: Discussionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled trial of a Chinese herbal <i>Sophora</i> flower formula in patients with symptomatic haemorrhoids: A preliminary study

Man¹,

Chen²,

Wang³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

show abstract

“…Interestingly, very little is known about the immune subsets that reside in the labia, despite the risk of sexually transmitted infection exposure, but LCs have been observed in labia at numbers similar to those observed in the ectocervix . Less studied still is the anorectal tract, but LCs have been observed in the anal canal . The foreskin is by far the most commonly studied tissue of the male genital tract in relation to sexually transmitted infections.…”

Section: Lcs In the Anogenital Tract: First Line Of Contactmentioning

confidence: 99%

“…50 Less studied still is the anorectal tract, but LCs have been observed in the anal canal. 51 The foreskin is by far the most commonly studied tissue of the male genital tract in relation to sexually transmitted infections.…”

Section: Langerinmentioning

confidence: 99%

Langerhans cells and sexual transmission of HIV and HSV

Botting

Rana

Bertram

et al. 2017

Reviews in Medical Virology

View full text Add to dashboard Cite

Langerhans cells (LCs) situated in stratified squamous epithelium of the skin and mucosal tissue are amongst the first cells that sexually transmitted pathogens encounter during transmission. They are potent antigen presenting cells and play a key role in the host mounting an appropriate immune response. As such, viruses have evolved complex strategies to manipulate these cells to facilitate successful transmission. One of best studied examples is HIV, which manipulates the natural function of these cells to interact with CD4 T cells, which are the main target cell for HIV in which rapid replication occurs. However, there is controversy in the literature as to the role that LCs play in this process. Langerhans cells also play a key role in the way the body mounts an immune response to HSV, and there is also a complex interplay between the transmission of HSV and HIV that involves LCs. In this article, we review both past and present literatures with a particular focus on a few very recent studies that shed new light on the role that LCs play in the transmission and immune response to these 2 pathogens.

show abstract

“…The mechanism by which HPV and HIV infection predisposes patients to anal carcinoma is poorly understood. Antigen‐presenting cells (APCs), including Langerhans’ cells (CD1a + ) and intra epithelial CD3 + lymphocytes, increase in anal HPV infection [6,7]. In addition, HPV seems to predispose anal mucosa to intraepithelial neoplasia (AIN 3), and it has been suggested that the potential role of HIV in increasing the risk of development of anal carcinoma is through compromising the local immunity system and consequently the re‐activation of HPV infection [8] .…”

Section: Introductionmentioning

confidence: 99%