Quantitative Analysis of Retinal Vessel Attenuation in Eyes with Retinitis Pigmentosa

Ma, Yaling; Kawasaki, Ryo; Dobson, Lucy; Ruddle, Jonathan B; Kearns, Lisa S.; Wong, Tien Yin; Mackey, David A.

doi:10.1167/iovs.11-8596

Cited by 57 publications

(93 citation statements)

References 26 publications

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“…IPL thinning and retinal amacrine neuronal dysfunction are observed in diabetic patients (27,28). Attenuation of the intraretinal vasculature is also highly correlated with progression of vision loss in retinitis pigmentosa (11), and our data strongly suggest that amacrine cell loss or dysfunction and ensuing intermediate plexus attenuation can accelerate photoreceptor atrophy in a murine model of the disease. Furthermore, preclinical experiments in rodent models of retinal degeneration have provided proof-of-concept evidence that stabilization of the intraretinal vasculature can retard photoreceptor atrophy (29).…”

Section: Discussionsupporting

confidence: 60%

“…This concept is supported by recent evidence suggesting that neuronal dysfunction and neurodegeneration are tightly correlated with microvascular dysfunction. Microvascular dysfunction and breakdown of the blood-retinal barrier in the retina are characteristic of retinal neurodegenerative disorders, such as retinitis pigmentosa and diabetic retinopathy (11,(25)(26)(27). IPL thinning and retinal amacrine neuronal dysfunction are observed in diabetic patients (27,28).…”

Section: Discussionmentioning

confidence: 99%

“…through VHL/HIF/VEGF signaling, to provide structural and trophic support to the vasculature, and perhaps even to prevent pathological neurovascular remodeling. These functions may be critical, since destabilized vascular networks in the retina are associated with dramatic visual defects (11). There is growing evidence that blood vessels and proangiogenic mitogens contribute to the pathogenesis of multiple neurological diseases (1,12).…”

Section: Introductionmentioning

confidence: 99%

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Neurovascular crosstalk between interneurons and capillaries is required for vision

et al. 2015

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neurovascular crosstalk between interneurons and capillaries is required for vision

et al. 2015

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“…Ma et al [27] used a computer-based program to evaluate retinal vessel diameters in RP patients and reported a correlation between vessel narrowing and visual field area. However, unlike in our study there was no control group and the vessels considered were all located within an area of 0.5-1 optic disc diameters from the optic disc, while we also considered more peripheral vessels.…”

Section: Discussionmentioning

confidence: 99%

Computer-Assisted Evaluation of Retinal Vessel Diameter in Retinitis Pigmentosa

et al. 2016

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Purpose: The evaluation of retinal vessel attenuation is very subjective and not sufficiently reliable in patients with retinitis pigmentosa (RP). We tested semiautomatic software capable of obtaining real-time measurements of vessel diameter. Methods: Retinal vessel diameter was calculated in 25 RP subjects and in 20 healthy controls. The Mann-Whitney test was used to compare the average values of RP patients with those of controls and subgroups of RP patients with different clinical features. Results: The retinal vessel diameter was significantly smaller in RP patients than in controls (p < 0.001). In particular, vessel diameters were smaller in older subjects, in patients with worse ERG responses, and in patients with more severe visual field loss. Conclusions: Computer-assisted analysis of retinal fundus pictures may be helpful in the diagnosis of RP and in monitoring disease progression.

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“…Vessel attenuation is thought predominantly to reflect the reduced metabolic demand of the degenerated retina, where loss of oxygen consumption leads to an increase in local oxygen levels in the retina, ultimately resulting in vasoconstriction (Yu & Cringle 2005; Ma et al. 2012). Clinical reports using various procedures support these findings, including measurements of subfoveal blood flow assessed using laser Doppler flowmetry (Grunwald et al.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Takagi

Hirami

Takahashi

et al. 2018

Acta Ophthalmologica

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PurposeTo investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti®) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA).MethodsThis was an age‐ and refraction‐matched case–control study. Consecutive patients with a best‐corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid (ISe) and external limiting membrane (ELM), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I‐2e of the Goldmann perimeter were analysed using mixed‐effects regression analysis.ResultsFoveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP, flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of ISe (p = 0.001) and ELM (p = 0.002) and the I‐2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399).ConclusionOptical coherence tomography angiography (OCTA)‐measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.

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Quantitative Analysis of Retinal Vessel Attenuation in Eyes with Retinitis Pigmentosa

Abstract: In RP patients, the severity of visual field loss is correlated with retinal vessel attenuation. Quantitative retinal vessel caliber measurement may be a useful additional clinical marker for monitoring progression of RP or potential treatment response.

Cited by 57 publications

References 26 publications

Neurovascular crosstalk between interneurons and capillaries is required for vision

Neurovascular crosstalk between interneurons and capillaries is required for vision

Computer-Assisted Evaluation of Retinal Vessel Diameter in Retinitis Pigmentosa

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

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