Quantitative analysis of rat inner ear blood flow using the iodo[14C]antipyrine technique

Lyon, Michael J.; Jensen, Ricky C

doi:10.1016/s0378-5955(00)00270-7

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…In addition, decreases in hair cell number have been found to be linearly related to age [17], consistent with our functional change in OCR. Increasing age is associated with decreased blood flow to the utricle [14] and attenuation of the neural response to otolith activation. [24] This is supported by the attenuated otolith-ocular responses of older subjects during linear acceleration stimuli.…”

Section: Discussionmentioning

confidence: 99%

Loss of otolith function with age is associated with increased postural sway measures

Serrador

Lipsitz

Gopalakrishnan

et al. 2009

Neuroscience Letters

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Section: Discussionmentioning

confidence: 99%

Loss of otolith function with age is associated with increased postural sway measures

Serrador

Lipsitz

Gopalakrishnan

et al. 2009

Neuroscience Letters

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“…Olds and Lyon [15] concluded that the local metabolic rate of glucose utilization for the rat vestibular endorgans is similar with the utricle and saccule and significantly higher than that of for the superior, posterior, or lateral canal ampullae. Lyon and Jensen [11] asserted that blood flow to all of the vestibular endorgans from rats is similar. They did not find significantly different metabolism and blood flow between three semicircular canal ampullae in the rat.…”

Section: Discussionmentioning

confidence: 99%

Semiquantitative Vestibulotoxicity to Subablative and Ablative Treated Gerbil Cristae Using Gentamicin or Streptomycin

Yamamoto

Slepecky

Suzuki

et al. 2004

Acta Histochem. Cytochem

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Semiquantitative histological evaluation was performed on inner ears from Mongolian gerbils to study vestibular damages using ototoxic drugs. Comparisons were made between animals receiving five daily injections of gentamicin/gelfoam slurry, streptomycin/gelfoam slurry, saline/gelfoam slurry and noninjected controls. For gentamicin treated ears, when percent decrease of nuclei in sensory cell layer was compared, the damage to the sensory cells was significantly more severe in the posterior crista than in the superior and lateral crista from two of three gerbils. For streptomycin treated ears, when percent decrease of nuclei in sensory cell layer was compared, the damage to the posterior crista was similar to superior and lateral crista. These results indicate that our models are useful for detecting different vestibulotoxicity among three cristae.

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“…Blood flow was scaled up from measurements made on guinea pig inner ear (17), which is one-tenth the volume of the human inner ear (8,21). Vascular compartment volume was derived from blood flow by using values of tissue perfusion (ml ⅐ 100 g Ϫ1 ⅐ min Ϫ1 ) for rat cochlea and vestibular sensory organs (13). Doubling or halving these two parameters resulted in only small quantitative but not qualitative differences in model simulations.…”

Section: Physiological Model Of Inner Ear Inert Gas Kineticsmentioning

confidence: 99%

Biophysical basis for inner ear decompression sickness

Doolette

Mitchell

2003

Journal of Applied Physiology

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Isolated inner ear decompression sickness (DCS) is recognized in deep diving involving breathing of helium-oxygen mixtures, particularly when breathing gas is switched to a nitrogen-rich mixture during decompression. The biophysical basis for this selective vulnerability of the inner ear to DCS has not been established. A compartmental model of inert gas kinetics in the human inner ear was constructed from anatomical and physiological parameters described in the literature and used to simulate inert gas tensions in the inner ear during deep dives and breathing-gas substitutions that have been reported to cause inner ear DCS. The model predicts considerable supersaturation, and therefore possible bubble formation, during the initial phase of a conventional decompression. Counterdiffusion of helium and nitrogen from the perilymph may produce supersaturation in the membranous labyrinth and endolymph after switching to a nitrogen-rich breathing mixture even without decompression. Conventional decompression algorithms may result in inadequate decompression for the inner ear for deep dives. Breathing-gas switches should be scheduled deep or shallow to avoid the period of maximum supersaturation resulting from decompression.

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Quantitative analysis of rat inner ear blood flow using the iodo[14C]antipyrine technique

Cited by 4 publications

References 48 publications

Loss of otolith function with age is associated with increased postural sway measures

Loss of otolith function with age is associated with increased postural sway measures

Semiquantitative Vestibulotoxicity to Subablative and Ablative Treated Gerbil Cristae Using Gentamicin or Streptomycin

Biophysical basis for inner ear decompression sickness

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