Quantitative analysis of quadriceps muscle biopsy

Doriguzzi, C.; Mongini, Tiziana; Palmucci, L.; Gagnor, Enrico; Schiffer, Davide

doi:10.1016/0022-510x(84)90020-0

Cited by 11 publications

(1 citation statement)

References 36 publications

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“…8 The minimum diameter of normal vastus lateralis muscle fibres ranges from 30 to 70 µm for women and 40-80 µm for men. 9,10 In the 12 patients studied, the minimum diameter of the 2B fibres at all three time points and of the 2A fibres postoperatively was below this normal range. The range for normal area of type 1 and 2 fibres is 4120-7275µm 2 and 4230-6457µm 2 for subjects in the 60-65 years age group.…”

Section: Group 1 Histopathology: Muscle Fibre Typing and Size Analysismentioning

confidence: 83%

Quadriceps muscle wasting persists 5 months after total hip arthroplasty for osteoarthritis of the hip: a pilot study

Reardon¹,

Galea²,

Dennett

et al. 2001

Internal Medicine Journal

121

102

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There is significant ipsilateral quadriceps atrophy and weakness with 2A and 2B fibre atrophy preoperatively in patients with osteoarthritis of the hip with exacerbation and further atrophy of all three fibre types 5 days postoperatively. Postoperative follow up showed that the reduction in ipsilateral quadriceps muscle thickness persisted at 5 months despite physical rehabilitation. Patients did note significant improvement in pain postoperatively and improvement on functional assessment with the TUG test. Other therapeutic strategies may have to be developed to reverse disuse muscle atrophy.

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Section: Group 1 Histopathology: Muscle Fibre Typing and Size Analysismentioning

confidence: 83%

Quadriceps muscle wasting persists 5 months after total hip arthroplasty for osteoarthritis of the hip: a pilot study

Reardon¹,

Galea²,

Dennett

et al. 2001

Internal Medicine Journal

121

102

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Additional biochemical criteria in the differential diagnosis of myositis

Zimmermann¹,

Langohr

Wiethölter³

et al. 1987

J Neurol

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Thirty-six biopsy specimens of human biceps and vastus lateralis muscles were examined by histometric analysis and determination of enzyme activities (phosphorylase, triosephosphate dehydrogenase, 3-hydroxacyl-CoA-dehydrogenase, lactate dehydrogenase, hexose isomerase, citrate synthetase, 6-phosphogluconate dehydrogenase). The series included 13 specimens from patients suffering from a benign form of muscular dystrophy (limb girdle and Becker type of muscular dystrophy) and 12 specimens from patients with an acute (n = 5) or chronic (n = 7) form of myositis. Muscle fibres were atrophic in myositis and hypertrophic (with an increased variation of fibre diameters) in muscular dystrophies, as has been shown previously. When myositis samples were compared with either normal or dystrophic muscles, a highly significant lowering of glycolytic enzyme activity was found in chronic myositis, while the activity of 6-phosphogluconate dehydrogenase was elevated to highly significant levels. Measurements of the latter enzyme's activity might be of additional value in differentiating chronic forms of myositis from benign muscular dystrophies.

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