Quantitative analysis of poly- and perfluoroalkyl compounds in water matrices using high resolution mass spectrometry: Optimization for a laser diode thermal desorption method

Munoz, Gabriel; Duy, Sung Vo; Budzinski, Hélène; Labadie, Pierre; Liu, Jinxia; Sauvé, Sébastien

doi:10.1016/j.aca.2015.04.015

Cited by 41 publications

(19 citation statements)

References 43 publications

(50 reference statements)

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“…This may be due to both the original mode of environmental release (as an aerosol, application to soil, and aqueous discharge) and the inverse relationship between PFAS mobility and chain length. 44 The MRLs (10–90 ng/L) in the UCMR3 database are up to 2 orders of magnitude higher than the limit of quantitation in most published studies, 45−49 and more than 10 times higher than the drinking water limit (1 ng/L) suggested by human and animal studies. 26,50 Because PFASs are detectable in virtually all parts of the environment, 5,7,9,13,14,20,44,51 we infer that the large fraction of samples below reporting limits (Table S4) is driven in part by high MRLs.…”

Section: Results and Discussionmentioning

confidence: 95%

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants

Andrews

Lindstrom

et al. 2016

Environ. Sci. Technol. Lett.

900

711

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Drinking water contamination with poly- and perfluoroalkyl substances (PFASs) poses risks to the developmental, immune, metabolic, and endocrine health of consumers. We present a spatial analysis of 2013–2015 national drinking water PFAS concentrations from the U.S. Environmental Protection Agency’s (US EPA) third Unregulated Contaminant Monitoring Rule (UCMR3) program. The number of industrial sites that manufacture or use these compounds, the number of military fire training areas, and the number of wastewater treatment plants are all significant predictors of PFAS detection frequencies and concentrations in public water supplies. Among samples with detectable PFAS levels, each additional military site within a watershed’s eight-digit hydrologic unit is associated with a 20% increase in PFHxS, a 10% increase in both PFHpA and PFOA, and a 35% increase in PFOS. The number of civilian airports with personnel trained in the use of aqueous film-forming foams is significantly associated with the detection of PFASs above the minimal reporting level. We find drinking water supplies for 6 million U.S. residents exceed US EPA’s lifetime health advisory (70 ng/L) for PFOS and PFOA. Lower analytical reporting limits and additional sampling of smaller utilities serving <10000 individuals and private wells would greatly assist in further identifying PFAS contamination sources.

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Section: Results and Discussionmentioning

confidence: 95%

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants

Andrews

Lindstrom

et al. 2016

Environ. Sci. Technol. Lett.

900

711

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“…Matrix effects were evaluated by comparing solvent-based analyte to internal standard area ratios to those of brown trout extracts spiked post-preparation, corrected by the non-spiked sample initial contribution. 47 Method trueness was controlled through the analysis of NIST SRM 1947 reference samples (n = 4) (Lake Michigan Fish Tissue) (SI Table S7). The concentrations determined for PFOS and PFCAs were in excellent agreement with previous reports.…”

Section: Pfas Chemical Analysesmentioning

confidence: 99%

Evidence for the Trophic Transfer of Perfluoroalkylated Substances in a Temperate Macrotidal Estuary

Munoz

Budzinski

Babut

et al. 2017

Environ. Sci. Technol.

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The present survey examines the trophodynamics of a suite of 19 perfluoroalkyl substances (PFASs) in a temperate macrotidal estuary (Gironde, SW France). Across the 147 biota samples (18 taxa) collected, perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and C-C perfluoroalkyl carboxylates (PFCAs) were the most-recurrent analytes. ΣPFASs ranged between 0.66-45 ng per g of wet weight of the whole body. Benthic organisms had relatively high ΣPFASs compared to demersal organisms and displayed specific composition profiles with higher relative abundances of C and C PFCAs. Trophic magnification factors (TMFs) were determined through the use of linear mixed effect models including censored data, thereby considering data below detection limits as well as the interspecific variability of δN and PFAS levels (random effects). TMFs were almost consistently >1 in the benthic food web as well as when considering all data pooled together, providing evidence for the biomagnification of several PFASs in estuarine environments. In addition, in contrast with previous observations, TMFs determined in the estuarine benthic web were found to significantly decrease with increasing chain length for C-C PFCAs and C-C perfluoroalkyl sulfonates. This suggests that PFAS chemical structure might not be necessarily predictive of TMFs, which are also influenced by the trophic web characteristics.

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“…Chromatographic operating conditions were adapted from a procedure initially developed by Labadie and Chevreuil (2011 (Munoz et al, 2015b). The mass scan range was set at 150-1000 m/z (full scan MS mode).…”

Section: Instrumental Analysismentioning

confidence: 99%

Analysis of zwitterionic, cationic, and anionic poly- and perfluoroalkyl surfactants in sediments by liquid chromatography polarity-switching electrospray ionization coupled to high resolution mass spectrometry

Munoz

Duy

Labadie

et al. 2016

Talanta

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A new analytical method is proposed for the determination of a wide span of fluoroalkylated surfactants (PFASs) of various chain lengths and polarities in sediments, including newly-identified compounds such as zwitterionic and cationic PFASs. Extraction conditions were optimized so as to maintain a common preparation procedure for all analytes (recovery range: 60-110%). Instrumental analysis was performed with ultra-high performance liquid chromatography coupled to Orbitrap mass spectrometry through polarity-switching electrospray ionization. Calibration curves with excellent coefficients of determination (R(2)>0.994) were generally obtained over 0.002-10ngg(-1) dry weight (dw) and limits of detection were in the range 0.0006-0.46 ng g(-1) dw. Intra-day precision remained<9% and inter-day precision<23%. While perfluorooctane sulfonate (PFOS) generally prevailed over other perfluoroalkyl acids (PFAAs) in sediments from mainland France, fluorotelomer sulfonamide amines and fluorotelomer sulfonamide betaines were also ubiquitous in these samples, especially in the vicinity of airports wherein firefighting training activities may occur on a regular basis.

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Quantitative analysis of poly- and perfluoroalkyl compounds in water matrices using high resolution mass spectrometry: Optimization for a laser diode thermal desorption method

Cited by 41 publications

References 43 publications

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants

Evidence for the Trophic Transfer of Perfluoroalkylated Substances in a Temperate Macrotidal Estuary

Analysis of zwitterionic, cationic, and anionic poly- and perfluoroalkyl surfactants in sediments by liquid chromatography polarity-switching electrospray ionization coupled to high resolution mass spectrometry

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