Quantitative Analysis of Paracetamol, Acetylcysteine and Guaifenesin in Commercial Cold Medicines by UV-Vis Spectroscopy

Tunca, Aysel Kucuk

doi:10.15764/ache.2014.01004

Cited by 4 publications

References 11 publications

(9 reference statements)

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Photo-oxidative degradation of polyacids derived ceria nanoparticle modulation for chemical mechanical polishing

Kim

Hong

Seok

et al. 2022

Sci Rep

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The effects of photo-oxidative degradation of polyacids at various concentrations and with different durations of ultraviolet (UV) irradiation on the photo-reduction of ceria nanoparticles were investigated. The effect of UV-treated ceria on the performance of chemical mechanical polishing (CMP) for the dielectric layer was also evaluated. When the polyacids were exposed to UV light, they underwent photo-oxidation with consumption of the dissolved oxygen in slurry. UV-treated ceria particles formed oxygen vacancies by absorbing photon energy, resulting in increased Ce3+ ions concentration on the surface, and when the oxygen level of the solution was lowered by the photo-oxidation of polymers, the formation of Ce3+ ions was promoted from 14.2 to 36.5%. Furthermore, chain scissions of polymers occurred during the oxidation process, and polyacids with lower molecular weights were found to be effective in ceria particle dispersion in terms of the decrease in the mean diameter and size distribution maintaining under 0.1 of polydispersity index. With increasing polyacid concentration and UV irradiation time, the Ce3+ concentration and the dispersity of ceria both increased due to the photo-oxidative degradation of the polymer; this enhanced the CMP performance in terms of 87% improved material removal rate and 48% lowered wafer surface roughness.

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Photo-oxidative degradation of polyacids derived ceria nanoparticle modulation for chemical mechanical polishing

Kim

Hong

Seok

et al. 2022

Sci Rep

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High-Sensitive and Selective Spectroscopic Detection of Guaifenesin in Multiple Dosage Forms and Human Plasma

mikawy,

Magdy,

Mohamed

et al. 2023

Preprint

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A Simple Stability-Indicating UPLC Method for the Concurrent Assessment of Paracetamol and Caffeine in Pharmaceutical Formulations

Ahmad¹,

Hassan²,

Ahmad³

et al. 2023

Separations

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A fixed-dose combination of paracetamol (PCM) and caffeine (CAF) tablets/capsules is the most frequently used over-the-counter medicine for fever and headache. In this paper, a simple, reliable, sensitive, rapid, and stability-indicating ultra-performance liquid chromatography (UPLC) analytical method was proposed for simultaneously assessing PCM and CAF in pharmaceutical formulations. The UPLC method was developed on an Acquity UPLC® CSHTM C18 column, and the column oven temperature was maintained at 35 ± 5 °C with isocratic elution by using a solution of methanol and water (30:70, v/v). The maximum absorbance of PCM and CAF was observed at 272.5 nm. The flow rate was 0.2 mL/min, and the injection volume was 1 µL, with the total run time of 2 min for the separation of PCM and CAF. The proposed UPLC method was validated according to the ICH guidelines, and it demonstrated excellent linearity, with correlation coefficients of 0.9995 and 0.9999 over the concentration ranges of 40–400 and 7–70 ng/mL for PCM and CAF, respectively. The mean retention times of 0.82 ± 0.0 and 1.16 ± 0.02 were observed for PCM and CAF, respectively. The limits of detection and quantification were 16.62 and 3.86 for PCM, respectively, and 50.37 and 11.70 for CAF, respectively. PCM and CAF were subjected to acidic, alkali, oxidative, phytochemical, dry-heat, and wet-heat degradation. The method was found to well separate the analytes’ peaks from degradation peaks, with no alterations in retention times. The proposed method is linear, precise, accurate, specific, and robust, and it can indicate stability and be used for the quantitative assessment of pharmaceutical formulations comprising PCM and CAF within a short period of time.

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Quantitative Analysis of Paracetamol, Acetylcysteine and Guaifenesin in Commercial Cold Medicines by UV-Vis Spectroscopy

Cited by 4 publications

References 11 publications

Photo-oxidative degradation of polyacids derived ceria nanoparticle modulation for chemical mechanical polishing

Photo-oxidative degradation of polyacids derived ceria nanoparticle modulation for chemical mechanical polishing

High-Sensitive and Selective Spectroscopic Detection of Guaifenesin in Multiple Dosage Forms and Human Plasma

A Simple Stability-Indicating UPLC Method for the Concurrent Assessment of Paracetamol and Caffeine in Pharmaceutical Formulations

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