Quantitative Analysis of Pancreatic Fat in Children with Obesity Using Magnetic Resonance Imaging and Ultrasonography

Lee, Mu Sook; Lee, Jeong Sub; Kim, Bong Soo; Kim, Doo Ri; Kang, Ki Soo

doi:10.5223/pghn.2021.24.6.555

Cited by 3 publications

(1 citation statement)

References 25 publications

(39 reference statements)

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“…Conventional ultrasound is simple and convenient, but can only provide semi-quantitative analysis, and the location of pancreas at the retroperitoneum behind the stomach or colon limits the accessibility, plus, the intestinal gas can easily interfere with the examination. 4 MRI is currently the most accurate way to quantify PFD, 5 , 6 but it is time-consuming and expensive compared to CT, thus not ideal for routine use. Conventional CT scan is a practical modality for quantifying PFD.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Pancreatic Fat by Quantitative CT in Type 2 Diabetes Mellitus

Li¹,

Yue²,

Chen³

et al. 2022

IJGM

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Objective To characterize the pancreatic fat deposition (PFD) in patients with type 2 diabetes mellitus (T2DM) by quantitative computed tomography (QCT) and investigate the relationship between PFD and clinical metabolic parameters and islet function. Materials and Methods A total of 150 patients with T2DM and 93 age-matched healthy subjects underwent QCT to quantify PFD were included. PFD and various biochemical parameters were correlated by statistical methods and multiple stepwise linear regression modeling. Results PFD measured by QCT in the T2DM group was statistically higher than that in the healthy control group, and the pancreatic CT value was statistically lower than that in the control group. The QCT measured PFD was negatively correlated with the pancreatic CT values (P < 0.001), and positively correlated with triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), visceral fat area (VAT) and insulin resistance index (HOMA-IR) (P < 0.05) in the T2DM patients. Multiple stepwise linear regression analysis identified PFD as the dependent variable factor for T2DM. Conclusion This study suggests QCT as a reliable technique in measuring PFD in T2DM. High PFD is positively correlated with the degree of insulin resistance and may play an important role in islet cell dysfunction in T2DM.

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Section: Introductionmentioning

confidence: 99%