Quantitative analysis of orbital soft tissues on computed tomography to assess the activity of thyroid-associated orbitopathy

Byun, Jun Soo; Moon, Nam Ju; Lee, Jeong Kyu

doi:10.1007/s00417-016-3538-0

Cited by 43 publications

(30 citation statements)

References 27 publications

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“…The CAS is a valid score because there is correlation between pretreatment CAS and response to the immunomodulation. The CAS is useful for assessment of activity, but it is less useful for monitoring changes over time [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of lacrimal glands in thyroid eye disease with diffusion-weighted magnetic resonance imaging

Razek¹,

El-Hadidy²,

El-Metwaly³

et al. 2019

Pol J Radiol

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Purpose: To assess the lacrimal glands in patients with thyroid eye disease with diffusion-weighted magnetic resonance (MR) imaging. Material and methods: This study was carried out on 44 consecutive patients (17 males, 27 females, with mean age 36 years) with thyroid eye disease and 20 age-and sex-matched volunteers. They underwent diffusion-weighted MR imaging of the orbit. The apparent diffusion coefficient (ADC) values of the lacrimal glands were calculated and correlated with the clinical activity score (CAS). Results: The mean ADC of lacrimal glands in thyroid eye disease (1.73 × 10-3 mm 2 /s) was significantly higher (p = 0.001) than that of volunteers (1.52 × 10-3 mm 2 /s). The cutoff ADC value of lacrimal gland used for differentiation of thyroid eye disease from volunteers was 1.62 × 10-3 mm 2 /s with an area under the curve value of 0.95 and an accuracy of 96%. There was significant difference (p = 0.03) in the ADC of the lacrimal glands in patients with active (n = 24) and inactive (n = 20) disease. The cutoff ADC value of the lacrimal gland used to suspect active disease was 1.76 × 10-3 mm 2 /s with an area under the curve value of 0.80 and an accuracy of 82%. There was positive correlation between the ADC value of the lacrimal glands and CAS (r = 0.73, p = 0.001). Conclusions: The ADC of the lacrimal glands is a non-invasive imaging parameter that can be used for diagnosis of thyroid eye disease and to predict the active form of the disease.

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Section: Discussionmentioning

confidence: 99%

“…Few studies discuss the lacrimal gland involvement in thyroid eye disease. Computed to-mography and isotope study are used to assess lacrimal glands in patients with thyroid eye disease; however, they are associated with radiation exposure [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Assessment of lacrimal glands in thyroid eye disease with diffusion-weighted magnetic resonance imaging

Razek¹,

El-Hadidy²,

El-Metwaly³

et al. 2019

Pol J Radiol

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“…There are some reports described the utility of CT HU for the evaluation of soft tissues. Byun et al found a direct correlation between the in ammatory activity and the density of extraocular fat and lacrimal gland by using HUs in patients with thyroid-associated orbitopathy, and they concluded that the density could predict active in ammation [3]. Another report by Chikui et al revealed Lipoma had a speci c range of CT HU values and displaced the surrounding soft tissue [11].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, computed tomography (CT) scan is also one of the conventional modalities to assess knee OA. CT is excellent not only for depicting cortical bone and soft tissue calci cations [3], but also for the assessment of soft tissues [4]. It offers better visualization of subchondral bone cysts and osteophytes compared with MRI and radiography, and also helps surgical planning preoperatively [5].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Degeneration of Posterior Cruciate Ligament Using CT Hounsfield Unit in Knee Osteoarthritis

Sumida

Nakasa

Ishikawa

et al. 2020

Preprint

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Background: The degeneration of posterior cruciate ligament (PCL) is often seen in knee osteoarthritis (OA), however there is no established method for its evaluation. The purpose of this study is to investigate whether Hounsfield unit (HU) using CT (computed tomography) could be a useful scale to evaluate the degeneration of PCL in knee OA.Methods: Knee OA treated with total knee arthroplasty (21 patients, 21 knees) and non-osteoarthritic knees (21 patients, 21 knees) were prospectively studied. All PCLs in the knees were analyzed by CT scan. PCL in sagittal section was divided into three regions: proximal, middle and distal portions. The HU value of PCL at each area was measured. In osteoarthritic knees, tissues from PCL were collected and histologically graded.Results: The HU value in OA and non-OA was 70.7 and 88.4 HU (p<0.05) at proximal region, 75.7 HU and 85.3 (p<0.05) at central region and 82.3 and 86.5 HU (p>0.05) at distal region, respectively. The degeneration of PCL was graded as follows; mild: 1 case, moderate: 3 cases and severe: 17 cases at proximal portion and mild: 16 cases, moderate: 4 cases and severe: 1 case at distal portion. The HU value was 84.5 HU for mild, 72.1 HU for moderate and 70.6 HU for severe (mild versus moderate: p<0.05, mild versus severe: p<0.05, moderate versus severe: p>0.05).Conclusions: In knee OA, lower HU value in PCL indicates progression of degeneration. The CT HU value could be a useful measurement to predict the grade of degeneration of PCL.

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“…Volume or distribution changes of the soft tissue caused by orbital trauma and orbital relative diseases (such as orbital fracture, thyroid-associated ophthalmopathy (TAO), intraorbital tumor and so on) may lead to diplopia, restricted ocular movement and even impairment of visual function [3,4]. Precise assessment of intraorbital soft tissue is essential for diagnosis of intraorbital disorders, effect evaluation of treatment and planning for surgical intervention [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

An accurate interactive segmentation and volume calculation of orbital soft tissue for orbital reconstruction after enucleation

Ning

Gao

et al. 2019

BMC Ophthalmol

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Background: Accurate measurement and reconstruction of orbital soft tissue is important to diagnosis and treatment of orbital diseases. This study applied an interactive graph cut method to orbital soft tissue precise segmentation and calculation in computerized tomography (CT) images, and to estimate its application in orbital reconstruction. Methods: The interactive graph cut method was introduced to segment extraocular muscle and intraorbital fat in CT images. Intra-and inter-observer variability of tissue volume measured by graph cut segmentation was validated. Accuracy and reliability of the method was accessed by comparing with manual delineation and commercial medical image software. Intraorbital structure of 10 patients after enucleation surgery was reconstructed based on graph cut segmentation and soft tissue volume were compared within two different surgical techniques. Results: Both muscle and fat tissue segmentation results of graph cut method showed good consistency with ground truth in phantom data. There were no significant differences in muscle calculations between observers or segmental methods (p > 0.05). Graph cut results of fat tissue had coincidental variable trend with ground truth which could identify 0.1cm 3 variation. The mean performance time of graph cut segmentation was significantly shorter than manual delineation and commercial software (p < 0.001). Jaccard similarity and Dice coefficient of graph cut method were 0.767 ± 0.045 and 0.836 ± 0.032 for human normal extraocular muscle segmentation. The measurements of fat tissue were significantly better in graph cut than those in commercial software (p < 0.05). Orbital soft tissue volume was decreased in post-enucleation orbit than that in normal orbit (p < 0.05). Conclusion: The graph cut method was validated to have good accuracy, reliability and efficiency in orbit soft tissue segmentation. It could discern minor volume changes of soft tissue. The interactive segmenting technique would be a valuable tool for dynamic analysis and prediction of therapeutic effect and orbital reconstruction.

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Quantitative analysis of orbital soft tissues on computed tomography to assess the activity of thyroid-associated orbitopathy

Abstract: The measurements of orbital soft tissue volume and density using CT scans can be used as a reliable and feasible technique to establish active inflammation in patients with TAO.

Cited by 43 publications

References 27 publications

Assessment of lacrimal glands in thyroid eye disease with diffusion-weighted magnetic resonance imaging

Assessment of lacrimal glands in thyroid eye disease with diffusion-weighted magnetic resonance imaging

The Evaluation of Degeneration of Posterior Cruciate Ligament Using CT Hounsfield Unit in Knee Osteoarthritis

An accurate interactive segmentation and volume calculation of orbital soft tissue for orbital reconstruction after enucleation

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