Quantitative analysis of nimesulide in plasma by thin-layer chromatography: Application to pharmacokinetic studies in man

Miljković, Branislava; Brzaković, Branka; Kovačević, Ivan; Agbaba, Danica; Pokrajac, M.

doi:10.1556/jpc.16.2003.3.8

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…The samples were subjected to liquid-liquid extraction and the metabolites were separated and characterized by TLC and electron-impact mass spectrometry respectively [129]. Different HPTLC methods were discussed for determination of NMD in human plasma and its application in human studies [130,131]. Table 3D indicates the details of the chromatographic conditions.…”

Section: Chromatographic Methodsmentioning

confidence: 99%

An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices

Rao

Meena

Akkinepally

2005

Journal of Pharmaceutical and Biomedical Analysis

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Section: Chromatographic Methodsmentioning

confidence: 99%

An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices

Rao

Meena

Akkinepally

2005

Journal of Pharmaceutical and Biomedical Analysis

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“…The quantitative limit of nimesulide is 0.5 g/ml. 54 . A method for quantifying Sparfloxacin in human plasma was developed by Shah et al PPT was used to extract the analyte from human plasma samples.…”

Section: Hptlcmentioning

confidence: 99%

Recent Upgradation in Bioanalytical Studies

Shelke

Rishipathak

2022

Biosci., Biotech. Res. Asia

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Analytical methodologies are critical throughout the medicine development process, including marketing and post-marketing studies. The advancement of bio-analytical techniques has resulted in a dynamic field with many exciting potentials for further advancement in the future. Bio-analysis is commonly utilised in the pharmaceutical drug development of drug's and its metabolites' quantitative levels. The goal is to undertake pharmacokinetic and pharmacodynamic studies, as well as kinetics, toxicokinetics, bioequivalence, and exposure studies. Bioanalytical research employs a variety of bioanalytical techniques, including new instrumental techniques, separation techniques, and ligand-Indused test. This study emphasizes the importance of bio-analytical techniques and hyphenated devices in evaluating drug bio-analysis and the role of several current bio-analytical techniques such as LC-Mass, HPLC-PDA, UPLC-Mass spectroscopy, HPTLC, LC-Tandem, AAS, ICP-Mass.etc., and their recent modernization in drug analytical and bio-analysis investigations

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“…In the pharmaceutical industry, TLC can be successfully applied to the identification and impurity determination in active pharmaceutical ingredients, assay of the finished products [4]. Planar chromatography is also used for determination of different drugs in biological samples [5][6][7]. The method is especially useful when rapid analysis of numerous samples is needed.…”

Section: Introductionmentioning

confidence: 99%

Determination of some psychotropic drugs in human plasma by HPTLC

Wróblewski

Petruczynik

Waksmundzka‐Hajnos

2014

Acta Chromatographica

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Summary. Psychotropic drugs: desipramine, olanzapine and mitrazapine were chromatographed on cyanopropyl-silica and Diol-silica thin layers using various nonaqueous and aqueous eluents.The best results were obtained with addition of ammonia to nonaqueous eluent on both adsorbents. On the basis of the optimization, systems for extraction from human plasma and quantitative determination of investigated drugs were selected.RP18 encaped SPE columns conditioned and pre-eluted with acetonitrile:water: ammonium buffer at pH 8.6 (5:5:2) and eluted with methanol:water (9:1) containing 2% acetic acid were used for sample preparation with high recoveries of all investigated drugs. Diol and CN plates with mixture of 15% methanol in diisopropyl ether + 1% ammonia were used for quantitative analysis by a calibration curve method.

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Quantitative analysis of nimesulide in plasma by thin-layer chromatography: Application to pharmacokinetic studies in man

Cited by 10 publications

References 7 publications

An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices

An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices

Recent Upgradation in Bioanalytical Studies

Determination of some psychotropic drugs in human plasma by HPTLC

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