Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis

Yamaguchi, Junko; Aihara, Michiko; Kobayashi, Yusuke; Kambara, Takeshi; Ikezawa, Zenrō

doi:10.1016/j.jdermsci.2008.08.011

Cited by 122 publications

(117 citation statements)

References 43 publications

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“…111 The serum level of the nerve growth factor (NGF) is significantly higher in AD compared to controls, and correlates with the severity of itch, erythema, scale/xerosis and eosinophil count. 112 There is increased expression of NGF in the lesional compared to non-lesional AD and the number of mast cell-nerve fibers (NF) contacts correlates with SCORAD and itch in lesional skin. Nicotinic acetylcholine receptor a7 mRNA, a marker for the non-neuronal cholinergic system (NNCS) was significantly lower in lesional AD skin at baseline.…”

Section: Neurogenic Inflammationmentioning

confidence: 99%

Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

Agache

Akdiş

2016

Allergology International

159

133

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Discoveries from basic science research in the last decade have brought significant progress in knowledge of pathophysiologic processes of allergic diseases, with a compelling impact on understanding of the natural history, risk prediction, treatment selection or mechanism-specific prevention strategies. The view of the pathophysiology of allergic diseases developed from a mechanistic approach, with a focus on symptoms and organ function, to the recognition of a complex network of immunological pathways. Several subtypes of inflammation and complex immune-regulatory networks and the reasons for their failure are now described, that open the way for the development of new diagnostic tools and innovative targeted-treatments. An endotype is a subtype of a disease condition, which is defined by a distinct pathophysiological mechanism, whereas a disease phenotype defines any observable characteristic of a disease without any implication of a mechanism. Another key word linked to disease endotyping is biomarker that is measured and evaluated to examine any biological or pathogenic processes, including response to a therapeutic intervention. These three keywords will be discussed more and more in the future with the upcoming efforts to revolutionize patient care in the direction of precision medicine and precision health. The understanding of disease endotypes based on pathophysiological principles and their validation across clinically meaningful outcomes in asthma, allergic rhinitis, chronic rhinosinusitis, atopic dermatitis and food allergy will be crucial for the success of precision medicine as a new approach to patient management.

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Section: Neurogenic Inflammationmentioning

confidence: 99%

Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

Agache

Akdiş

2016

Allergology International

159

133

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“…NGF and artemin have also been recently shown to sensitize pruriceptors and thus enhance itching upon injection intradermally (Rukwied et al 2013;Murota et al 2012). Consistent with their role in regulating itch, the level of NGF and artemin was significantly elevated in the skin from patients with atopic dermatitis (Yamaguchi et al 2009;Murota et al 2012). Intriguingly, NGF sensitized only cowhage-induced itch, but not histamine-induced itch (Rukwied et al 2013), which is mainly mediated by TRPV1.…”

Section: Modulation Of Itch By Inflammatory Mediatorsmentioning

confidence: 76%

Targeting TRP ion channels for itch relief

Zhang

2014

Naunyn-Schmiedeberg's Arch Pharmacol

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Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.

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“…Likewise, increased expressions of neurotrophin-4 were found in lesional skin of AD patients [95]. Of further importance, NGF levels were well-correlated with symptom severity in AD and decreased by effective therapies [96], further supporting the etiological role of this neurotrophin. In good accord with these findings, atopic human keratinocytes, co-cultured with porcine sensory neurons, were shown to induce an increased neurite outgrowth which effect was mediated by NGF and GDNF [97].…”

Section: Role Of Neuropeptides and Neurotrophinsmentioning

confidence: 80%

TRP Channels and Pruritus

Tóth¹,

Bı́ró²

2013

TOPAINJ

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Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators, itch-selective pruriceptors, sensory afferent networks, spinal cord neurons, and certain central nervous system regions. In this review, we first introduce major features of the pruriceptive system. We then focus on defining the roles of transient receptor potential (TRP) ion channels in skin-coupled itch and provide compelling evidence that certain thermosensitive TRP channels (especially TRPV1, TRPV3, TRPV4, and TRPA1) are indeed key players in pruritus pathogenesis. Finally, we propose TRP-centered future experimental directions towards the therapeutic targeting of TRP channels in the clinical management of itch.

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Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis

Cited by 122 publications

References 43 publications

Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

Targeting TRP ion channels for itch relief

TRP Channels and Pruritus

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