Quantitative analysis of nailfold capillary abnormalities in patients with connective tissue diseases

Ohtsuka, Tsutomu

doi:10.1046/j.1365-4362.1999.00773.x

Cited by 23 publications

(22 citation statements)

References 41 publications

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“…In fact, a wide variety of microvascular anomalies and great variation from SLE patient to SLE patient has been reported. 3,4,8,9,11,13,18 Moreover, we have demonstrated a significant correlation between disease activity and the overall capillaroscopic patterns. To our knowledge, this observation has not been previously reported, and it may confirm that pathologic changes in the capillary beds are important because these anomalies may be considered a red flag.…”

Section: Discussionmentioning

confidence: 53%

Evaluation of Nailfold Videocapillaroscopic Abnormalities in Patients With Systemic Lupus Erythematosus

Ingegnoli

Zeni

Meani

et al. 2005

JCR: Journal of Clinical Rheumatology

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Section: Discussionmentioning

confidence: 53%

Evaluation of Nailfold Videocapillaroscopic Abnormalities in Patients With Systemic Lupus Erythematosus

Ingegnoli

Zeni

Meani

et al. 2005

JCR: Journal of Clinical Rheumatology

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“…14 One of the intense research activities using OCT microangiography is to image blood flow within microcirculatory tissue bed of human skin. Since vascular involvement in pathogenesis of diseases in human has been reported, [18][19][20] cutaneous microcirculation has become of much interest as a desirable target for identifying microcirculatory dysfunction due to its easy access for examination. 21 Thus, the assessment of skin microvasculature may be useful for the prognosis and diagnosis of vascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Improved microcirculation imaging of human skinin vivousing optical microangiography with a correlation mapping mask

Choi¹,

Reif²,

Yousefi³

et al. 2014

J. Biomed. Opt

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Abstract. Optical microangiography based on optical coherence tomography (OCT) is prone to noise that arises from a static tissue region. Here, we propose a method that can significantly reduce this noise. The method is developed based on an approach that uses the magnitude information of OCT signals to produce tissue microangiograms, especially suitable for the case where a swept-source OCT system is deployed. By combined use of two existing OCT microangiography methods-ultrahigh-sensitive optical microangiography (UHS-OMAG) and correlation mapping OCT (cmOCT)-the final tissue microangiogram is generated by masking UHS-OMAG image using the binary representation of cmOCT image. We find that this process masks the residual static artifacts while preserving the vessel structures. The noise rejection capability of the masked approach (termed as mOMAG) is tested on a tissue-like flow phantom as well as an in vivo human skin tissue. Compared to UHS-OMAG and cmOCT, we demonstrate that the proposed method is capable of achieving improved signal-to-noise ratio in providing microcirculation images. Finally, we show its clinical potential by quantitatively assessing the vascular difference between a burn scar and a normal skin of human subject in vivo. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…The most common capillaroscopy device consists of an optical microscope with an attached camera and a cold external light source. Videocapillaroscopy with ×100–200 magnification attached to a monitor with a specific program that allows storage and image processing gives detailed observations of individual capillaries 8,9 . Capillaroscopy is a simple and useful technique that may allow us to differentiate Raynaud’s phenomenon (RP) into secondary RP and primary types, giving reliable information regarding the severity of the disease 10 .…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic detection of nail fold capillary abnormality in patients with systemic sclerosis

Ohtsuka

2011

The Journal of Dermatology

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The diagnosis of systemic sclerosis (SSc) is often difficult. The purpose of the present study was to find the distribution of nail fold capillary abnormality in SSc. Sixty-two patients with SSc (male : female = 7:55, age 21-86 years, mean 60.1) admitted to the outpatient clinics were studied. Eighteen age- and sex-matched normal subjects, 28 patients with systemic lupus erythematosus (SLE) and 10 with dermatomyositis (DM) were also studied. Nail fold capillary loops were observed under immersion oil at a magnification of ×40 with a light microscope. Dilated capillaries, nail fold bleeding and avascular areas were found by dermoscopic observation. The distribution of dilated capillaries, nail fold bleeding and avascular areas in normal controls showed in one (5.6%), one (5.6%) and four cases (22.2%), respectively. The distribution of dilated capillaries, nail fold bleeding and avascular area in SSc patients showed in 27 cases (43.5%), eight cases (12.9%) and 16 cases (25.8%), respectively. The distribution of dilated capillaries and/or nail fold bleeding in SSc patients (29/62, 46.8%) was significantly elevated than that of normal controls (2/18, 11.1%) (P < 0.01). The distribution of overall abnormality in SSc (30/62, 48.4%) showed no significant difference compared with that of normal controls (4/18, 22.2%). Sensitivity and specificity for dilated capillaries and/or nail fold bleeding and overall nail fold abnormality in SSc patients compared with normal controls was calculated as 40.8% and 93.5%, 34.8% and 88.2%, respectively. Dermoscopic observation of dilated capillaries and/or nail fold bleeding is a sensitive and specific method for the detection of SSc.

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Quantitative analysis of nailfold capillary abnormalities in patients with connective tissue diseases

Abstract: Nailfold capillary abnormalities are useful for detecting vascular abnormality in clinical practice. These facts stress the importance of nailfold capillary abnormalities in SSc.

Cited by 23 publications

References 41 publications

Evaluation of Nailfold Videocapillaroscopic Abnormalities in Patients With Systemic Lupus Erythematosus

Evaluation of Nailfold Videocapillaroscopic Abnormalities in Patients With Systemic Lupus Erythematosus

Improved microcirculation imaging of human skinin vivousing optical microangiography with a correlation mapping mask

Dermoscopic detection of nail fold capillary abnormality in patients with systemic sclerosis

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