Quantitative Analysis of Lower Leg Adipose Tissue Distribution in Youth with Myelomeningocele

Lorenzana, Daniel J.; Mueske, Nicole M.; Ryan, Deirdre; Speybroeck, Alexander Van; Wren, Tishya A. L.

doi:10.1177/0883073816634858

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…19 Lorenzana et al 20 confirmed an increase in intramuscular fat in the lower limbs, which, although it is a risk factor for metabolic complications compared to subcutaneous fat deposits, may justify an increase in peripheral versus central FM%. Other studies 23 also confirmed peripheral FM localization, particularly in the lower limbs.…”

Section: Discussionmentioning

confidence: 98%

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Body composition and energy expenditure in a population of children and adolescents with myelomeningocele

Caminiti

Sauré

Weglinski

et al. 2018

Arch Argent Pediatr

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Introduction.Myelomeningocele is a congenital defect that occurs when the neural tube fails to close completely. It causes body composition alterations and a high prevalence of obesity. It is difficult to detect the most adequate indicator for a nutritional diagnosis due to the impossibility of recording accurate anthropometric measurements. Objective. To describe body composition, resting energy expenditure and metabolic disorders in a population of patients with myelomeningocele managed at "Hospital Garrahan" by comparing obese patients with myelomeningocele and a control population with multifactorial obesity. Population and methods. An anthropometry, an impedance analysis, skinfold equations, arm circumference equations, indirect calorimetry, and biochemical determinations were done to all patients with myelomeningocele between June 2013 and April 2014, once the informed consent had been signed. Results. 131 patients aged 0.7-18.6 years were assessed; they were classified according to their body mass index Z-score into low weight (15%), normal weight (42%), overweight (12%), and obese (31%). A high correlation (r: 20.74) was observed between the fat mass % measured by impedance analysis versus that estimated using skinfolds. Patients with a high fat mass % had a higher body mass index Z-score than those with a normal fat mass % (1.07 versus -0.27, p: 0.0001) although both values were within normal parameters. A lower resting energy expenditure was observed among obese patients with myelomeningocele than predicted and in comparison with multifactorial obese controls. Conclusions. A high percentage of overweight/ obesity was found in the population with myelomeningocele. Skinfold equations would be more adequate to detect obesity. Obese patients with myelomeningocele had a lower resting energy expenditure than predicted and in comparison with controls. Energy indication should be customized.

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Section: Discussionmentioning

confidence: 98%

“…Consistently with such lack of association, recent studies have demonstrated a greater lower limb FM in this population of patients. 20 It is also possible that the reduced number of patients in this category could have resulted in an underestimation of the relationship between both indicators.…”

Section: Discussionmentioning

confidence: 99%

Body composition and energy expenditure in a population of children and adolescents with myelomeningocele

Caminiti

Sauré

Weglinski

et al. 2018

Arch Argent Pediatr

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“…En coincidencia con la falta de asociación, estudios recientes demuestran mayor localización de MG en los miembros inferiores en esta población de pacientes. 20 Existe también la posibilidad de que el reducido número de pacientes en esta categoría pudo haber subestimado la relación entre ambos indicadores.…”

Section: Discussionunclassified

Composición corporal y gasto energético en población de niños y adolescentes con mielomeningocele

2018

Arch Argent Pediatr

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“…DXA measurements are influenced by bone and body size and inhomogeneous fat distribution, ( 23,24 ) which are particularly problematic for children who are growing and for patient populations with short stature and high body fat as is common in SB. ( 14,25–27 )…”

Section: Introductionmentioning

confidence: 99%

Quantitative Computed Tomography Assessment of Bone Deficits in Ambulatory Children and Adolescents with Spina Bifida: Importance of Puberty

et al. 2020

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Pathologic fractures of the femur and tibia are common in youth with spina bifida (SB). These fractures may be associated with deficient bone accrual due to decreased ambulation and skeletal loading. This prospective cohort study used quantitative computed tomography (QCT) to assess three‐dimensional (3D) bone properties in children and adolescents with SB. Eighty‐three ambulatory youth with SB underwent QCT imaging of the tibia at up to four annual visits between ages 6 to 16 years (294 total visits averaging 3.5 visits/patient). A total of 177 controls without disability and 10 non‐ambulatory youth with SB underwent imaging once. Bone geometric properties (cortical bone area, cross‐sectional area, cortical thickness, cortical density, and moments of inertia) were measured at the mid‐diaphysis (50% of bone length); cross‐sectional area, cancellous density, and density‐weighted area were measured in the proximal (13% of bone length) and distal (90% of bone length) metaphyses. Bone properties were compared between the ambulatory SB and control participants, among SB neurosegmental subgroups (sacral, low lumbar, mid lumbar and above) as a function of pubertal stage (prepubertal, pubertal, postpubertal), and considering SB type (myelomeningocele, lipomyelomeningocele) using linear mixed effects models adjusted for sex, age, height percentile, and body mass index (BMI) percentile. Only cancellous density of both metaphyses and weighted area of the proximal metaphysis differed between ambulatory children with SB and controls before puberty. However, significant deficits in all bone properties manifested during and after puberty as moderate bone growth in the SB group failed to keep pace with the large increases normally observed during puberty. The bone deficits primarily affected patients with myelomeningocele, and similar deficits were observed at all neurosegmental levels except that cancellous density was closer to normal in the sacral group. Descriptive analysis of the 10 non‐ambulatory youth with SB showed greater bone deficits than ambulatory children, particularly for cancellous density in the distal metaphysis. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

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Quantitative Analysis of Lower Leg Adipose Tissue Distribution in Youth with Myelomeningocele

Cited by 6 publications

References 31 publications

Body composition and energy expenditure in a population of children and adolescents with myelomeningocele

Body composition and energy expenditure in a population of children and adolescents with myelomeningocele

Composición corporal y gasto energético en población de niños y adolescentes con mielomeningocele

Quantitative Computed Tomography Assessment of Bone Deficits in Ambulatory Children and Adolescents with Spina Bifida: Importance of Puberty

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