Quantitative analysis of liquid formulations using FT-Raman spectroscopy and HPLC

Orkoula, Malvina; Kontoyannis, Christos G.; Markopoulou, Catherine K.; Koundourellis, John E.

doi:10.1016/j.jpba.2006.02.051

Cited by 21 publications

(9 citation statements)

References 16 publications

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“…Quantitative analysis of pharmaceutical compounds in various dosage forms has been performed using Raman spectroscopy (9)(10)(11). Some reports of the use of Raman spectroscopy for the identification of illicit drugs have been published (3)(4)(5)(6)(7)(8) and they show that this represents a good tool for identification of illicit drugs.…”

mentioning

confidence: 99%

Quantification of the Amphetamine Content in Seized Street Samples by Raman Spectroscopy

Katainen

Elomaa

Laakkonen

et al. 2006

Journal of Forensic Sciences

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A Raman spectroscopy method for determining the drug content of street samples of amphetamine was developed by dissolving samples in an acidic solution containing an internal standard (sodium dihydrogen phosphate). The Raman spectra of the samples were measured with a CDD-Raman spectrometer. Two Raman quantification methods were used: (1) relative peak heights of characteristic signals of the amphetamine and the internal standard; and (2) multivariate calibration by partial least squares (PLS) based on second derivative of the spectra. For the determination of the peak height ratio, the spectra were baseline corrected and the peak height ratio (h(amphetamine at 994 cm(-1) )/h(internal standard at 880 cm(-1) )) was calculated. For the PLS analysis, the wave number interval of 1300-630 cm(-1) (348 data points) was chosen. No manual baseline correction was performed, but the spectra were differentiated twice to obtain their second derivatives, which were further analyzed. The Raman results were well in line with validated reference LC results when the Raman samples were analyzed within 2 h after dissolution. The present results clearly show that Raman spectroscopy is a good tool for rapid (acquisition time 1 min) and accurate quantitative analysis of street samples that contain illicit drugs and unknown adulterants and impurities.

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confidence: 99%

Quantification of the Amphetamine Content in Seized Street Samples by Raman Spectroscopy

Katainen

Elomaa

Laakkonen

et al. 2006

Journal of Forensic Sciences

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“…Journal of Spectroscopy In this work, PCR was validated by evaluating the ANVISA RE no. 899/2003 figures of merit such as specificity, linearity, precision, and accuracy in the same way as Orkoula et al [47], Rossignoli et al [48], and Borio et al [49]. The PCR model showed excellent linearity with a correlation coefficient r = 0 994, high precision, and RSD as low as 1.76%.…”

Section: Discussionmentioning

confidence: 55%

“…The PCR model showed excellent linearity with a correlation coefficient r = 0 994, high precision, and RSD as low as 1.76%. Corroborating the method validation employed by Orkoula et al [47], commercial samples of the reference drug containing 500 mg/mL of dipyrone were used to validate the model. These samples showed very low errors, not exceeding 2.5%, suggesting that dispersive Raman spectroscopy using an optical probe can detect the amount of API present in the commercial samples, and all samples conformed, which is different to the study of Knappmann and Melo [32].…”

Section: Discussionmentioning

confidence: 99%

Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions

Guimarães

Moreira

Lourenço

et al. 2018

Journal of Spectroscopy

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This work employed a quantitative model based on Raman spectroscopy and principal component regression (RS/PCR) to quantify the active ingredient dipyrone (metamizole) in commercially available formulations as an analytical methodology for quality control in the pharmaceutical industry. Raman spectra were collected using a dispersive Raman spectrometer (830 nm, 250 mW excitation, and 20 s exposure time) coupled to a Raman probe. Solutions of dipyrone diluted in water in the range of 80 to 120% of the concentration of commercial formulations (500 mg/mL) were used to develop a calibration model based on PCR to obtain the figures of merit for class I validation from the Brazilian Sanitary Surveillance Agency (ANVISA, RE no. 899/2003). This spectral model was then used to predict the concentration of dipyrone in commercial formulations from distinct brands with 500 mg/mL. A prediction error of 6.5 mg/mL (1.3%) was found for this PCR model using the diluted samples. Commercial formulations had predicted concentrations with a difference below 5.0% compared to the label concentration, indicating the applicability of Raman spectroscopy for quality control in the final product.

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“…Such techniques require prior extraction of the active substance. The literature describes numerous methods of quantitative determination of diphenhyramine, based on the use of high performance liquid chromatography, but it has not been validated by the Ukraine Pharmaceutical requirements [12][13][14][15].…”

Section: с л загородний с а васюкmentioning

confidence: 99%

Validation of quantitative determination methods of diphenhyramine tablets by high performance liquid chromatography

Zagorodniy¹,

Vasyuk²

2015

ZMJ

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Quantitative analysis of liquid formulations using FT-Raman spectroscopy and HPLC

Cited by 21 publications

References 16 publications

Quantification of the Amphetamine Content in Seized Street Samples by Raman Spectroscopy

Quantification of the Amphetamine Content in Seized Street Samples by Raman Spectroscopy

Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions

Validation of quantitative determination methods of diphenhyramine tablets by high performance liquid chromatography

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