1999
DOI: 10.1016/s0003-2670(98)00605-9
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Quantitative analysis of human serum albumin–drug interactions using reversed-phase and ion-exchange liquid chromatography

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Cited by 14 publications
(10 citation statements)
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“…Several attempts have been done to generate mathematical models to predict binding affinities to HSA from drug molecular structure, mainly for specific families of compounds. [43][44][45][46][47][48][49][50][51][52][53] Since much of the data has been obtained from high performance affinity chromatography experiments, these models are usually referred as QSRR (Quantitative Structure-Retention Relationships) ones, because the predicted variable is the compound retention factor in the column (K 0 HSA ). 44 Whether we call them QSRR models, or, using a more typical name, QSAR (Quantitative Structure-Activity Relationships) models, the present section attempts to gather and describe the corresponding equations present in the bibliography.…”
Section: Q S a R M O D E L S F O R D R U G -B I N D I N G A F F I Nmentioning
confidence: 99%
See 1 more Smart Citation
“…Several attempts have been done to generate mathematical models to predict binding affinities to HSA from drug molecular structure, mainly for specific families of compounds. [43][44][45][46][47][48][49][50][51][52][53] Since much of the data has been obtained from high performance affinity chromatography experiments, these models are usually referred as QSRR (Quantitative Structure-Retention Relationships) ones, because the predicted variable is the compound retention factor in the column (K 0 HSA ). 44 Whether we call them QSRR models, or, using a more typical name, QSAR (Quantitative Structure-Activity Relationships) models, the present section attempts to gather and describe the corresponding equations present in the bibliography.…”
Section: Q S a R M O D E L S F O R D R U G -B I N D I N G A F F I Nmentioning
confidence: 99%
“…There are also some models derived for heterogeneous (although very small) sets of compounds in the bibliography. 51,52 In this case the binding constants were not obtained through affinity chromatography with HSA-immobilized stationary phases, but from a modified Hummer-Dryer method using purified HSA, and further analysis of the data using Scatchard plots. In a first article by these authors, a set of seven acidic drugs were studied.…”
Section: Table III Qsar Models For Drug-hsa Binding In the Bibliographymentioning
confidence: 99%
“…However, the throughput of these assays is limited because of the need to directly detect the free compound, typically through HPLC or radiometric detection. As a result, alternative methods that make use of chromatography, [29] mass spectrometry, [30] microcalorimetry, [31] and fluorescence spectroscopy [32,33] have been proposed for measuring the affinity constant of a compound for HSA. NMR has also been used to monitor compound binding to albumin, with the earliest report being from Oleg Jardetzky's lab in the study of penicillin binding to albumin.…”
Section: Measuring Compound Affinity For Human Serum Albuminmentioning
confidence: 99%
“…The main binding forces are hydrophobic interaction and ion-ion interaction, and specific steric effects may not be important. Previously, acidic drug-HSA and basic drug-HSA binding affinities were successfully determined by a combination of reversed-phase and ionexchange liquid chromatography without albumin [15][16][17]. Guanidino groups of arginine should work as anionexchange groups and carboxyl groups of aspartic and glutamic acids should work as cation-exchange groups.…”
mentioning
confidence: 99%