Quantitative Analysis of EEG Power Spectra in Experimental Hepatic Encephalopathy

Popken, R.J.; Kropveld, D.; Oosting, J.; Chamuleau, R. A. F. M.

doi:10.1159/000117971

Cited by 16 publications

(6 citation statements)

References 2 publications

(2 reference statements)

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“…Five days before a (sham)-PCS was performed four golden skull electrodes were implanted as published previously (16). EEG spectral analysis was carried out for four EEG power band regions within the range of l-26.5 Hz.…”

Section: Methodsmentioning

confidence: 99%

The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy

Vogels¹,

Steynen²,

Maas³

et al. 1997

Journal of Hepatology

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The effects of ammonia and portal-systemic shunting on brain metabolims, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy Vogels, B.A.P.M.; van Steynen, B.; Maas, M.A.W.; Jorning, G.G.A.; Chamuleau, R.A.F.M. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Background/Aims: The pathogenetic factors contributing to encephalopathy in portacaval shunted rats with hyperammonaemia were studied. Methods: Hyperammonaemia was induced by ammonium-acetate infusions in portacaval shunted rats (2.8 mmol-kg bw-'*h-l; AI-portacaval shunted rats) and in sham-portacaval shunted rats (6.5 mmol-kg bw-l-h-'; AI-NORM rats). Severity of encephalopathy was quantified by clinical grading and EEG spectral analysis. Changes in brain metabolites were assessed by amino acid analysis of brain cortex homogenates, whereas changes in amino acids with neurotransmitter activity were assessed in cerebrospinal fluid; brain water content was measured by subtracting dry from wet brain weights and intracranial pressure was measured by a pressure transducer connected to a cisterna magna cannula. Results:Although similar increased blood and brain ammonia concentrations were obtained in both experimental groups, only AI-portacaval shunted rats developed encephalopathy, associated with a significant increase in intracranial pressure. HEPATIC encephalopathy (HE) is generally regarded to be a reversible neuropsychiatric syndrome in patients with liver failure. It is often associated with portal-systemic shunting of blood, which may occur spontaneously or be surgically induced. Although the pathogenesis of HE is probably multi- Conclusions: These results indicate that hyperammonaemia alone does not induce encephalopathy, whereas portal-systemic shunting adds an essential contribution to the pathogenesis of encephalopathy. It is hypothesised that the larger increase in brain glutamine in AI-portacaval shunted rats than in AI-NORM rats is responsible for increased brain concentrations of aromatic amino acids, for cell swelling and for extracellular release of glutamate and aspartate. This might promote encephalopathy. If cell swelling is not restricted, intracranial hypertension will develop

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Section: Methodsmentioning

confidence: 99%

The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy

Vogels¹,

Steynen²,

Maas³

et al. 1997

Journal of Hepatology

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“…For our specific purpose (quantification of the rat's EEG during the development of hepatic encephalopathy), the described system works very well [Popken et al, 1983],…”

Section: Discussionmentioning

confidence: 99%

“…Electrodes: 4 golden skull electrodes taken from PROM-adapter sockets were stereotactically implanted, as described by Popken et al [1983], Two derivations were made: a fronto-occipital on the left hemisphere and an occipito-occipital.…”

Section: Methods and Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

A Computerised EEG-Analyzing System for Small Laboratory Animals

Kropveld¹,

Chamuleau²,

Popken³

et al. 1983

Neuropsychobiology

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The experimental setup, including instrumentation and software packaging, is described for the use of a minicomputer as an on-line analyzing system of the EEG in rats. Complete fast Fourier transformation of the EEG sampled in 15 episodes of 10 s each is plotted out within 7 min after the start of registration of the EEG signal. The influence of high voltage spikes, spindles and baseline drift on the power density spectrum is shown and a method of clipping is presented that excludes these kinds of artefacts. The normalized standard error of the power density estimate is determined by the smoothing procedure and is at maximum 26%.

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“…O EEG é descrito como uma ferramenta para avaliação de encefalopatias de diversas causas inclusive doença de Creutzfeldt-Jakob (Furlan et al, 1981;Wieser et al, 2006); encefalopatias urêmica (Jonkman et al, 1992), hipóxico-isquêmica (Doyle et al, 2007), hepática (Popken et al, 1983;Amodio et al, 1996); abstinência de metanfetamina (Newton et al, 2003); overdose de baclofeno (Fakhoury et al, 1998); leucemia linfoblástica aguda (Korinthenberg et al, 2002) e coma (Young, 2000.…”

Section: Encefalopatias E Delíriounclassified

Estudo da análise da razão alfa/teta em pacientes com doença de Alzheimer provável

Schmidt¹

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Quantitative Analysis of EEG Power Spectra in Experimental Hepatic Encephalopathy

Cited by 16 publications

References 2 publications

The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy

The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy

A Computerised EEG-Analyzing System for Small Laboratory Animals

Estudo da análise da razão alfa/teta em pacientes com doença de Alzheimer provável

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