Quantitative analysis of contrast-enhanced ultrasonography: differentiating focal nodular hyperplasia from hepatocellular carcinoma

Abstract

Objective: To explore the potential of quantitative analysis of contrast-enhanced ultrasonography (CEUS) in differentiating focal nodular hyperplasia (FNH) from hepatocellular carcinoma (HCC).Methods: 34 cases of FNH and 66 cases of HCC (all lesions ,5 cm) were studied using CEUS to evaluate enhancement patterns and using analytic software Sonoliver ® ( The quantitative features of maximum of intensity (IMAX), rise slope (RS), rise time (RT) and time to peak (TTP) were compared between the two groups and applied to further characterise both FNH and HCC with hypoenhancing patterns in the late phase on CEUS.Results: The sensitivity and specificity of CEUS for diagnosis of FNH were 67.6% and 93.9%, respectively. For quantitative analysis, IMAX and RS in FNHs were significantly higher than those in HCCs (p,0.05), while RT and

Focal Nodular Hyperplasia of the Liver: Contrast‐Enhanced Ultrasonographic Features With Sonazoid

“…In this study, 23 of 31 focal nodular hyperplasia lesions (74.2%) showed typical vascular patterns, including central stellate vascularity and centrifugal enhancement. These typical vascular patterns on CEUS have been well documented in previous studies, with a wide range of detection rates from 30% to 100% . Among these studies, Luo et al reported sensitivity of 82% for “diffuse enhancement with spoked‐wheel arteries” with Sonazoid, using intermittent scanning with a high mechanical index.…”

“…Recent studies have reported that CEUS can provide valuable information about the central feeding artery, spoked‐wheel vascularity, and the centrifugal filling pattern of focal nodular hyperplasia, which can lead to a confident diagnosis. However, most studies have been conducted with a contrast agent other than Sonazoid.…”

Quantitative dynamic contrast-enhanced ultrasound may help predict the outcome of hepatocellular carcinoma after microwave ablation

“…These parameters provide information about blood volume and blood flow, and have been compared between HCC and non-HCC liver lesions. Different studies have reported that DCE-US could reflect the perfusion characteristics and differentiate HCC from intrahepatic cholangiocarcinoma [24], focal nodular hyperplasia [25], and metastatic liver cancer [26]. In this study, four of the DCE-US parameters (IMAX, RT, TTP, and mTT) were significantly different between HCC and reference liver parenchyma.…”

Comparison of transducers with different frequencies in breast contrast-enhanced ultrasound (CEUS) using SonoVue as contrast agent

“…SonoVue® (Bracco, Plan-Les-Ouates, Switzerland), which consists of phospholipidstabilized microbubbles filled with sulfur hexafluoride, is the most widely used ultrasound contrast agent. 3,4 CEUS was originally developed for the differential diagnosis of focal lesions in the liver and has been successfully applied in clinical practice. Previous studies 5,6 have proved that CEUS could improve the diagnostic accuracy of breast lesions.…”