2024
DOI: 10.3390/proteomes12030021
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Quantitative Analysis of Complement Membrane Attack Complex Proteins Associated with Extracellular Vesicles

Illarion V. Turko

Abstract: Extracellular vesicles (EVs) represent a universal mechanism of intercellular communication in normal and pathological conditions. There are reports showing the presence of complement proteins in EV preparations, specifically those that can form a membrane attack complex (MAC). In the present work, we have used a quantitative mass spectrometry method that allows for the measurement of multiple targeted proteins in one experimental run. The quantification of MAC-forming proteins, namely C5b, C6, C7, C8, and C9,… Show more

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