Quantitative Analysis of Azodicarbonamide in Insulation Layers of Extruded Cables by HPLC–UV Detection

Shen, Sensen; Chang, Cuilan; Shen, Chenbo; Xu, Harvey; Miao, Shawn; Wills, Scott

doi:10.1007/s41664-021-00154-3

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to available literature protocols for the analysis of ADCA in DMSO/ dimethylformamide mixtures [15,17], the wavelength of 272 nm was selected as the best one in terms of tradeoff between removing solvent interference and achieving a sensitive detection. Recent studies aiming to accurately quantify traces of ADCA in various matrices have also used similar wavelengths, such as 276 nm or 280 nm [17,18]. Measurements were carried out in five chemical environments, starting from pure DMSO (D100, where D refers to DMSO and the number indicates its percentage fraction in the mixture) to pure water (D000), with intermediate DMSO:water mixtures at 80:20 (D080), 50:50 (D050) and 20:80 (D020) compositions.…”

Section: Solubility Measurementmentioning

confidence: 99%

On the solubility of azodicarbonamide in water/DMSO mixtures: an experimental and computational study

Macetti,

Sironi,

Rovida

et al. 2024

R. Soc. Open Sci.

View full text Add to dashboard Cite

This work aims at studying why azodicarbonamide (ADCA), a formally apolar compound with good hydrogen bond (HB) acceptors, is soluble only in polar aprotic solvents like dimethyl sulfoxide (DMSO) but not in water. Solubility measurements, as well as quantum mechanical and classical molecular dynamics simulations, were employed to tackle the problem. We found that in the liquid phase a polar conformer of ADCA ( µ = 8.7 D), unreported to date, is favoured under the enthalpic drive provided by a highly polar solvent. At the same time, the very high hydrogen bond propensity of water with itself prevents this solvent from providing an effective hydrogen bond-mediated solvation. Solvents bearing good HB acceptors, while lacking strong HB donors, contribute to further stabilizing solute–solvent adducts through weak and fluxional HBs that involve the amide groups of ADCA. Implications for the solubility of ADCA down to µ M concentrations were evaluated, also with the aid of classical simulations of solution nanodroplets.

show abstract