Quantitative analysis of astrocyte and axonal density relationships: Glia to neuron ratio in the optic nerve laminar regions

Chan, Gerald; Morgan, William H.; Yu, Dao‐Yi; Balaratnasingam, Chandrakumar

doi:10.1016/j.exer.2020.108154

Cited by 1 publication

(3 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Balaratnasingam and colleagues detailed astrocyte distribution in the lamina cribrosa, pre-laminar region, and post-laminar region of the porcine ONH [ 55 , 56 , 57 , 58 ]. Their results showed that astrocytes are the predominant glial cell in the optic nerve and that astrocytes in the ONH had radial, inter-digitating processes [ 56 , 57 ].…”

Section: Investigations Of Astrocyte Structure and Function In The Po...mentioning

confidence: 99%

“…They found an absence of GFAP staining in tissue that contained laminar plates [ 57 ]. The area occupied by GFAP+ astrocytes was significantly greater in the pre-laminar region compared to the post-laminar region and the lamina cribrosa, indicating that the pre-laminar region may have the greatest metabolic demand out of these three areas [ 57 , 58 ]. In the pre-laminar region, GFAP staining was seen in areas where neuronal staining was present, in spaces around axonal bundles, and along the inner limiting membrane [ 56 ].…”

Section: Investigations Of Astrocyte Structure and Function In The Po...mentioning

confidence: 99%

“…GFAP astrocytes that were present in the lamina cribrosa and post-laminar regions were also seen to closely associate with axonal bundles [ 56 ]. Additionally, higher regions of astrocyte density correlated to higher regions of axonal density in the ONH [ 58 ].…”

Section: Investigations Of Astrocyte Structure and Function In The Po...mentioning

confidence: 99%

See 2 more Smart Citations

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Purvis,

Fedorczak,

Prah

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Astrocytes are essential to virtually all brain processes, from ion homeostasis to neurovascular coupling to metabolism, and even play an active role in signaling and plasticity. Astrocytic dysfunction can be devastating to neighboring neurons made inherently vulnerable by their polarized, excitable membranes. Therefore, correcting astrocyte dysfunction is an attractive therapeutic target to enhance neuroprotection and recovery following acquired brain injury. However, the translation of such therapeutic strategies is hindered by a knowledge base dependent almost entirely on rodent data. To facilitate additional astrocytic research in the translatable pig model, we present a review of astrocyte findings from pig studies of health and disease. We hope that this review can serve as a road map for intrepid pig researchers interested in studying astrocyte biology.

show abstract