Quantitative analysis of amyloid plaques in a mouse model of Alzheimer’s disease by phase-contrast X-ray computed tomography

Photothermal ablation of amyloid aggregates by gold nanoparticles

“…The neuritic plaques [1] composed of ␤-amyloid (A␤) peptide in the brain of Alzheimer's disease (AD) patients, the most common cause of senile dementia [2], is primarily composed of A␤ and to a lesser extent A␤ . These peptides are used as the hallmark indicators of AD [3][4][5].…”

3d virtual histology of neuronal tissue by propagation-based x-ray phase-contrast tomography

“…The following chapter gives an outlook on the application of propagation-based phase-contrast tomography for imaging of structural changes occurring during neurodegenerative diseases, in particular at the examples of multiple sclerosis [22], Alzheimer's disease [119,137] and a mouse model for ischemic stroke [37].…”

Probing Alzheimer's Disease Pathology and Early Detection at the NSLS with Infrared, XRF, and DEI

“…Very high field micro-MRI has shown the ability to visualize in vivo plaques in mice [4]. More recently, phase contrast X-ray imaging, a synchrotron X-ray technique similar to DEI, was used to image individual plaques in AD-model transgenic mice ex vivo [5]. These new imaging methods use completely different contrast mechanisms to achieve the same goal of high-resolution, in vivo imaging of amyloid plaques.…”