Quantitative Analysis of Amoxicillin, Clavulanic Acid, and Ticarcillin in Multi-Wells by Liquid Chromatography/Electrospray Ionization Mass Spectrometry as a Strategy for Quality Control

Ashraf‐Khorassani, Mehdi; Taylor, Larry T.; Koeth, Laura; Roush, John A.

doi:10.1365/s10337-005-0641-5

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…There are several methods known in the literature for the individual and/or simultaneous determination of amoxicillin and clavulanic acid in human plasma and other biological matrix using UV [2,6,11,13] and MS/MS methods [3][4][5][7][8][9]12]. All MS/MS methods involve polarity switching, for monitoring the clavulanic acid in negative electrospray ionization mode.…”

Section: Determination Of Acquisition Parametersmentioning

confidence: 99%

Validated LC-MS/MS Method for the Concomitant Determination of Amoxicillin and Clavulanic Acid from Human Plasma

Balázsi¹,

Paizs²,

Irimie³

et al. 2017

Studia UBB Chemia

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ABSTRACT. The purpose of this study was the development and validation of an LC-MS/MS method, for the concomitant and rapid determination amoxicillin and clavulanic acid from human plasma. The sample workup involved a simple protein precipitation procedure. A core/shell type analytical column (50×2,1 mm, 2.6 Å) was used with PFP stationary phase. A mobile phase with high aqueous composition provided satisfactory separation with good accuracy and precision (stable ionization). The mass spectrometer was operated in positive electrospray ionization mode for both analytes and internal standard. The following parameters were evaluated for validation purpose: Selectivity, sensitivity, matrix effect, anticoagulant effect, linearity, precision and accuracy, recovery, analyte/IS stability in solvent/matrix and carryover. The validated calibration range was 190-22222 ng/ml for amoxicillin, and 147-4908 ng/ml for clavulanic acid. The correlation coefficient R 2 was at least 0.99 for both analytes. The validated method has been successfully used for the evaluation bioequivalence of generic amoxicillin/potassium clavulanate formulations.

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Section: Determination Of Acquisition Parametersmentioning

confidence: 99%

Validated LC-MS/MS Method for the Concomitant Determination of Amoxicillin and Clavulanic Acid from Human Plasma

Balázsi¹,

Paizs²,

Irimie³

et al. 2017

Studia UBB Chemia

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“…In this context, the application of various techniques such as thermal analysis [4] [5], chromatography [6], X-ray powder diffraction [4], [6], [7], [8], [9 ], [10], [11] among others are of a great importance for the control of raw materials used in the manufacture of medicines and for the control of finished drugs as well.…”

Section: Introductionmentioning

confidence: 99%

JST-DRX: A SOFTWARE TO GENERATE X-RAY POWDER DIFFRACTOGRAMS FROM PATENTS DATA (2q X I)

Tanaka¹,

Paiva‐Santos²,

Antônio³

2015

Proceedings of the International Symposium on Crystallography

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Current literature in mass spectrometry

2006

J. Mass Spectrom.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Books, Reviews & Symposia; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author (4 Weeks journals ‐ Search completed at 12th. Apr. 2006)

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Quantitative Analysis of Amoxicillin, Clavulanic Acid, and Ticarcillin in Multi-Wells by Liquid Chromatography/Electrospray Ionization Mass Spectrometry as a Strategy for Quality Control

Cited by 5 publications

References 23 publications

Validated LC-MS/MS Method for the Concomitant Determination of Amoxicillin and Clavulanic Acid from Human Plasma

Validated LC-MS/MS Method for the Concomitant Determination of Amoxicillin and Clavulanic Acid from Human Plasma

JST-DRX: A SOFTWARE TO GENERATE X-RAY POWDER DIFFRACTOGRAMS FROM PATENTS DATA (2q X I)

Current literature in mass spectrometry

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