Quantitative analysis of aconitine in body fluids in a case of aconitine poisoning

Cho, Yong Soo; Choi, Ho-Woong; Chun, Byeong Jo; Moon, Jeong Mi; Na, Joo Young

doi:10.1007/s12024-019-00211-5

Cited by 13 publications

(5 citation statements)

References 14 publications

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“…The mechanism of death in aconitine poisoning is generally attributed to a ventricular-type arrhythmia-causing failure of the cardiopulmonary system. Compared with previously reported cases of aconitine poisoning (12.1-39.1 ng/ml), we reported a concentration in the blood (16.4 ng/ml) within this reported range [10,17,18].…”

Section: Discussioncontrasting

confidence: 52%

Reflections on the aconitine poisoning

Yang

Zhang

Liu

et al. 2021

Journal of Forensic Sciences

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Section: Discussioncontrasting

confidence: 52%

Reflections on the aconitine poisoning

Yang

Zhang

Liu

et al. 2021

Journal of Forensic Sciences

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“…To the best of our knowledge, no exact lethal dose of aconitine has been reported to date. In one case of mortality reported in the literature, the patient’s antemortem aconitine blood concentration was 39.1 ng/mL, and the postmortem urine concentration was 67.4 ng/mL[ 9 ]. In our case, the aconitine concentration in the blood and urine was significantly higher than that reported in the aforementioned study, which is considered to be associated with the accumulation of oral aconitine from herbal medicinal wine that was repeatedly ingested 1 mo before the patient’s visit.…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial necrosis caused by aconitine poisoning: A case report

Liao¹,

Shen²,

Cai³

et al. 2022

World J Clin Cases

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BACKGROUND Herbal medicine has a long history of use in the prevention and treatment of disease and is becoming increasingly popular globally. However, there are also widespread concerns about its safety. Among them, the cardiotoxicity of aconitine has been described. CASE SUMMARY We report a case of a 61-year-old male with aconitine poisoning presenting with malignant arrhythmia and severe cardiogenic shock, which was successfully managed with aggressive advanced life support and heart transplantation. CONCLUSION This is the first case wherein in vivo cardiac pathology was obtained, confirming that aconitine caused acute myocardial necrosis.

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“…Furthermore, aconite also acts on the ventromedial nucleus in the hypothalamus which regulates the autonomic nervous system causing bradycardia and hypotension 6 . Toxicological analysis of aconite can be performed to detect the presence of aconitine or its metabolites using techniques such as liquid chromatography mass-spectrometry and immunoassays 8 . However, it is not available in Bhutan and diagnosis is mainly based on clinical grounds.…”

Section: Cardiotoxic Effects Of Poisoning From Aconite Root In a Midd...mentioning

confidence: 99%

Cardiotoxic effects of poisoning from aconite root in a middle-aged man in Bhutan: a case report

Sonam,

Dorji,

Rai

et al. 2024

Bhutan Health Journal

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Introduction: Poisoning is a major global health concern and a preventable cause of death. Aconite, an alkaloid found in the aconitum genus frequently leads to poisoning in Asian countries including Bhutan owing to its use in traditional medicine and religious items. Case presentation: A 47-year-old male consumed a tincture of aconite plant root and experienced vomiting, blurred vision, paraesthesia, and light headedness. On presentation to the emergency department, his vitals were normal but on subsequent close monitoring, he had premature ventricular contractions and sinus bradycardia leading to hypotension and shock. He was admitted to the intensive care unit for continuous cardiac monitoring and supportive treatment including atropine and noradrenaline. He reported subjective improvement, his vital signs improved and ECG returned to normal, enabling discharge after 5 days of admission. Conclusion: There is no specific antidote to aconite toxicity so the treatment is mainly supportive. It is imperative to implement proactive measures such as public awareness programs and dedicated research efforts to mitigate the risk of inadvertent toxicity resulting from aconite use.

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Quantitative analysis of aconitine in body fluids in a case of aconitine poisoning

Cited by 13 publications

References 14 publications

Reflections on the aconitine poisoning

Reflections on the aconitine poisoning

Acute myocardial necrosis caused by aconitine poisoning: A case report

Cardiotoxic effects of poisoning from aconite root in a middle-aged man in Bhutan: a case report

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