2019
DOI: 10.1007/s12024-019-00211-5
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Quantitative analysis of aconitine in body fluids in a case of aconitine poisoning

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Cited by 13 publications
(5 citation statements)
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“…The mechanism of death in aconitine poisoning is generally attributed to a ventricular-type arrhythmia-causing failure of the cardiopulmonary system. Compared with previously reported cases of aconitine poisoning (12.1-39.1 ng/ml), we reported a concentration in the blood (16.4 ng/ml) within this reported range [10,17,18].…”
Section: Discussioncontrasting
confidence: 52%
“…The mechanism of death in aconitine poisoning is generally attributed to a ventricular-type arrhythmia-causing failure of the cardiopulmonary system. Compared with previously reported cases of aconitine poisoning (12.1-39.1 ng/ml), we reported a concentration in the blood (16.4 ng/ml) within this reported range [10,17,18].…”
Section: Discussioncontrasting
confidence: 52%
“…To the best of our knowledge, no exact lethal dose of aconitine has been reported to date. In one case of mortality reported in the literature, the patient’s antemortem aconitine blood concentration was 39.1 ng/mL, and the postmortem urine concentration was 67.4 ng/mL[ 9 ]. In our case, the aconitine concentration in the blood and urine was significantly higher than that reported in the aforementioned study, which is considered to be associated with the accumulation of oral aconitine from herbal medicinal wine that was repeatedly ingested 1 mo before the patient’s visit.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, aconite also acts on the ventromedial nucleus in the hypothalamus which regulates the autonomic nervous system causing bradycardia and hypotension 6 . Toxicological analysis of aconite can be performed to detect the presence of aconitine or its metabolites using techniques such as liquid chromatography mass-spectrometry and immunoassays 8 . However, it is not available in Bhutan and diagnosis is mainly based on clinical grounds.…”
Section: Cardiotoxic Effects Of Poisoning From Aconite Root In a Midd...mentioning
confidence: 99%