Quantitative analysis of aberrant fatty acid composition of zebrafish hepatic lipids induced by organochlorine pesticide using stable isotope-coded transmethylation and gas chromatography-mass spectrometry

Zhong, Hongying; Dong, Linjie; Dong, Qingjian; Ke, Chao; Fu, Jieying; Wang, Xiaoli; Liu, Cong; Dai, Ling

doi:10.1007/s00216-012-6089-1

Cited by 9 publications

(2 citation statements)

References 45 publications

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“…Zebrafish exposed to 0.1 μg/L and 1 μg/L of DDT during 60 days displayed an increase in the saturated long chain fatty acids C16:0 and C18:0 along with monounsaturated C18:1n9 accompanied with a decrease of the levels of polyunsaturated fatty acids C20:3n3, C20:4n6, and C22:6n3 in a DDTconcentration-dependent manner. A decrease in the weight of the females was also observed for the concentration of 0.1 μg/L DDT (Zhong et al, 2012).…”

Section: Other Compoundsmentioning

confidence: 66%

Obesogens in the aquatic environment: an evolutionary and toxicological perspective

Capitão

Lyssimachou

Castro

et al. 2017

Environment International

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The rise of obesity in humans is a major health concern of our times, affecting an increasing proportion of the population worldwide. It is now evident that this phenomenon is not only associated with the lack of exercise and a balanced diet, but also due to environmental factors, such as exposure to environmental chemicals that interfere with lipid homeostasis. These chemicals, also known as obesogens, are present in a wide range of products of our daily life, such as cosmetics, paints, plastics, food cans and pesticide-treated food, among others. A growing body of evidences indicates that their action is not limited to mammals. Obesogens also end up in the aquatic environment, potentially affecting its ecosystems. In fact, reports show that some environmental chemicals are able to alter lipid homeostasis, impacting weight, lipid profile, signaling pathways and/or protein activity, of several taxa of aquatic animals. Such perturbations may give rise to physiological disorders and disease. Although largely unexplored from a comparative perspective, the key molecular components implicated in lipid homeostasis have likely appeared early in animal evolution. Therefore, it is not surprising that the obesogen effects are found in other animal groups beyond mammals. Collectively, data indicates that suspected obesogens impact lipid metabolism across phyla that have diverged over 600 million years ago. Thus, a consistent link between environmental chemical exposure and the obesity epidemic has emerged. This review aims to summarize the available information on the effects of putative obesogens in aquatic organisms, considering the similarities and differences of lipid homeostasis pathways among metazoans, thus contributing to a better understanding of the etiology of obesity in human populations. Finally, we identify the knowledge gaps in this field and we set future research priorities.

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Section: Other Compoundsmentioning

confidence: 66%

Obesogens in the aquatic environment: an evolutionary and toxicological perspective

Capitão

Lyssimachou

Castro

et al. 2017

Environment International

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“…For example, TCDD, a highly lipophilic pollutant, is reported to accumulate in WAT and cause lipodystrophy ( 15 ). A weight loss of female zebrafish was also observed after DDT exposure ( 48 ). Similar results were obtained in our study that benzene exposure could also induce lipodystrophy of WAT, accompanied by increasing trend of circulating NEFA level.…”

Section: Discussionmentioning

confidence: 97%

Benzene Exposure Leads to Lipodystrophy and Alters Endocrine Activity In Vivo and In Vitro

Cui

et al. 2022

Front. Endocrinol.

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Benzene is a ubiquitous pollutant and mainly accumulates in adipose tissue which has important roles in metabolic diseases. The latest studies reported that benzene exposure was associated with many metabolic disorders, while the effect of benzene exposure on adipose tissue remains unclear. We sought to investigate the effect using in vivo and in vitro experiments. Male adult C57BL/6J mice were exposed to benzene at 0, 1, 10 and 100 mg/kg body weight by intragastric gavage for 4 weeks. Mature adipocytes from 3T3-L1 cells were exposed to hydroquinone (HQ) at 0, 1, 5 and 25 μM for 24 hours. Besides the routine hematotoxicity, animal experiments also displayed significant body fat content decrease from 1 mg/kg. Interestingly, the circulating non-esterified fatty acid (NEFA) level increased from the lowest dose (ptrend < 0.05). Subsequent analysis indicated that body fat content decrease may be due to atrophy of white adipose tissue (WAT) upon benzene exposure. The average adipocyte area of WAT decreased significantly even from 1 mg/kg with no significant changes in total number of adipocytes. The percentages of small and large adipocytes in WAT began to significantly increase or decrease from 1 mg/kg (all p < 0.05), respectively. Critical genes involved in lipogenesis and lipolysis were dysregulated, which may account for the disruption of lipid homeostasis. The endocrine function of WAT was also disordered, manifested as significant decrease in adipokine levels, especially the leptin. In vitro cell experiments displayed similar findings in decreased fat content, dysregulated critical lipid metabolism genes, and disturbed endocrine function of adipocytes after HQ treatment. Pearson correlation analysis showed positive correlations between white blood cell (WBC) count with WAT fat content and plasma leptin level (r = 0.330, 0.344, both p < 0.05). This study shed light on the novel aspect that benzene exposure could induce lipodystrophy and disturb endocrine function of WAT, and the altered physiology of WAT might in turn affect benzene-induced hematotoxicity and metabolic disorders. The study provided new insight into understanding benzene-induced toxicity and the relationship between benzene and adipose tissue.

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The Roles of Diet and Habitat Use in Pesticide Bioaccumulation by Juvenile Chinook Salmon: Insights from Stable Isotopes and Fatty Acid Biomarkers

Anzalone,

Fuller,

Hartz

et al. 2024

Arch Environ Contam Toxicol

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Quantitative analysis of aberrant fatty acid composition of zebrafish hepatic lipids induced by organochlorine pesticide using stable isotope-coded transmethylation and gas chromatography-mass spectrometry

Cited by 9 publications

References 45 publications

Obesogens in the aquatic environment: an evolutionary and toxicological perspective

Obesogens in the aquatic environment: an evolutionary and toxicological perspective

Benzene Exposure Leads to Lipodystrophy and Alters Endocrine Activity In Vivo and In Vitro

The Roles of Diet and Habitat Use in Pesticide Bioaccumulation by Juvenile Chinook Salmon: Insights from Stable Isotopes and Fatty Acid Biomarkers

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