1937
DOI: 10.1021/ja01289a062
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Quantitative Acetylation of Amines by Means of Acetyl Chloride and Pyridine

Abstract: Quantitative Acetylation of Amines 2003 2. The benzoyl and o-chlorobenzoyl esters and 3. The structure of each of the seven phenols the -naphthylurethans of the seven phenols was established by synthesis.were prepared.East Lansing, Mich.

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Cited by 11 publications
(3 citation statements)
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“…However, Olson and Feldman (1937) (120) found the method of Smith and Bryant unsuitable for the quantitative determination of amines. Primary aromatic amines yielded widely varying results although secondary aromatic amines gave quantitative results; aliphatic amines gave very low results.…”
Section: General Macro Methodsmentioning
confidence: 99%
“…However, Olson and Feldman (1937) (120) found the method of Smith and Bryant unsuitable for the quantitative determination of amines. Primary aromatic amines yielded widely varying results although secondary aromatic amines gave quantitative results; aliphatic amines gave very low results.…”
Section: General Macro Methodsmentioning
confidence: 99%
“…Compounds containing these two functional groups are also routinely synthesized, and the two sources provide a variety of compounds for biological testing. While there are several methods for making amides and esters, the use of acyl chloride or acyl anhydride in a weak base like pyridine is usually employed, especially when the reactants are simple alcohols or amines [1]. Several other methods using mainly acetic anhydride with different bases and acids have been reported [2][3][4][5][6][7][8][9][10][11].…”
Section: Introductionmentioning
confidence: 99%
“…12 Few methods of acetylation of amines are known using ace- * For correspondence tyl chloride of which most common is the use of acetyl chloride in pyridine. 13 Acetyl chloride has also been used in combination with some fairly exotic reagents such as ZrOCl 2 •8H 2 O, 14 zinc dust 15 and thermally decomposed Ni-Fe-hydrotalcite. 16 However, owing to its aforementioned explosive nature when in contact with water and subsequent rapid hydrolysis, the use of this easily available and cost effective reagent in aqueous medium has proved elusive till date.…”
Section: Introductionmentioning
confidence: 99%