Quantitative 99 Tcm-HMPAO white blood cells and 67 Ga scanning in rheumatoid arthritis

Sj, Wang; Ch, Kao; Du, Cuiwei; MS, Lin; Sh, Yeh; Jl, Lan

doi:10.1097/00006231-199106000-00010

Cited by 4 publications

(1 citation statement)

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“…In all doubtful cases, following visual assessment, a semi-quantitative evaluation can be performed for the differential diagnosis of infection from non-specific uptake [ 69 , 71 , 76 , 77 ]. Regions of interest (ROIs) are drawn over the area of interest (usually with the highest uptake) and copied to a presumed normal reference tissue; contra-lateral bone is the best when available [ 69 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical indications, image acquisition and data interpretation for white blood cells and anti-granulocyte monoclonal antibody scintigraphy: an EANM procedural guideline

Signore

Jamar

Israel

et al. 2018

Eur J Nucl Med Mol Imaging

140

148

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IntroductionRadiolabelled autologous white blood cells (WBC) scintigraphy is being standardized all over the world to ensure high quality, specificity and reproducibility. Similarly, in many European countries radiolabelled anti-granulocyte antibodies (anti-G-mAb) are used instead of WBC with high diagnostic accuracy. The EANM Inflammation & Infection Committee is deeply involved in this process of standardization as a primary goal of the group.AimThe main aim of this guideline is to support and promote good clinical practice despite the complex environment of a national health care system with its ethical, economic and legal aspects that must also be taken into consideration.MethodAfter the standardization of the WBC labelling procedure (already published), a group of experts from the EANM Infection & Inflammation Committee developed and validated these guidelines based on published evidences.ResultsHere we describe image acquisition protocols, image display procedures and image analyses as well as image interpretation criteria for the use of radiolabelled WBC and monoclonal antigranulocyte antibodies. Clinical application for WBC and anti-G-mAb scintigraphy is also described.ConclusionsThese guidelines should be applied by all nuclear medicine centers in favor of a highly reproducible standardized practice.

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