“…In an experimental study, despite a fivefold increase in RMBF, systolic wall thickening increased by ϳ100% (26). In clinical studies, normal subjects demonstrated an increase in wall thickening with dobutamine of 70% to 120%, using echocardiography, magnetic resonance, and computed tomography (24,27,28). In contrast, our data demonstrate a five-to six-fold increase in sSR, with a similar increase in RMBF (Fig.…”