Quantitation of proteinuria with urinary protein/creatinine ratios and random testing with dipsticks in nephrotic children

Abitbol, Carolyn; Zilleruelo, Gastón; Frendlich, Michael; Strauss, José

doi:10.1016/s0022-3476(05)82881-1

Cited by 107 publications

(79 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The original diagnosis of NS was based on the presence of nephroticrange proteinuria, hypoalbuminemia, edema, and hypercholesterolemia (22). Nephrotic-range proteinuria was defined by a protein excretion in excess of 40 mg/m 2 per d and/or a urinary protein/creatinine ratio (UP/C) Ͼ1.0 mg/mg (normal Ͻ0.2 mg/mg) on random urine specimens obtained at the time of routine clinical visits (23). Patients who received vitamin D supplements or loop diuretics during the preceding 3 mo were excluded from the study.…”

Section: Patientsmentioning

confidence: 99%

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Freundlich¹,

Alonzo²,

Bellorín-Font³

et al. 2005

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Patients with nephrotic syndrome (NS), even with normal GFR, often display altered mineral homeostasis and abnormal bone histology. However, the latter, mostly osteomalacia and increased bone resorption, cannot be readily explained by the prevalent concentrations of parathyroid hormone and vitamin D metabolites. The transmembrane receptor activator of NF-B ligand (RANKL) of osteoblasts is essential for osteoclast formation and differentiation. Osteoblasts activity and the expression of RANKL were tested in cultures of normal human osteoblasts with sera obtained from patients with NS and normal GFR (129 ؎ 26 ml/min per 1.73 m 2 ) during relapse and remission of their NS. Osteoblasts that were cultured in vitro with sera during relapse displayed elevated concentrations of alkaline phosphatase (AP) and increased expression of RANKL. By contrast, during remission, AP concentrations were significantly lower (P < 0.05) and RANKL expression notably attenuated or absent. AP correlated with the proteinuria (r ‫؍‬ 0.5, P < 0.05) and was not significantly affected by the therapeutic administration of corticosteroids. Whereas parathyroid hormone levels were normal (35 ؎ 21 pg/ml), the serum markers of bone formation (osteocalcin and bone-specific alkaline phosphatase) were lower during relapse compared with remission. Thus, sera from patients with NS and normal GFR stimulate the activity of osteoblasts and upregulate their expression of RANKL. These alterations, more prominent during clinically active NS, are transient and reversible upon remission. These disturbances of bone biology may play an important pathogenic role in the abnormal bone histology observed in patients with NS even before a decline in GFR occurs.

show abstract

Section: Patientsmentioning

confidence: 99%

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Freundlich¹,

Alonzo²,

Bellorín-Font³

et al. 2005

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…The preferred method of measuring urinary protein excretion in patients with proteinuria is either the total protein-to-creatinine ratio or albumin-to-creatinine ratio for microalbuminuria on a random urine specimen KDOQI, 2002). These ratios on a random urine specimen correlate fairly closely with daily protein excretion in g/1.73 m 2 of body surface area (Ginsberg et al, 1983;Schwab et al, 1987;Abitbol et al, 1990;Steinhauslin & Wauters, 1995;Chitalia et al, 2001;Zelmanovitz et al, 1997;Bakker, 1999). Thus, a ratio of 4.9 (as with respective urinary protein and creatinine concentrations of 210 and 43 mg/dl) represents daily protein excretion of approximately 4.9 g/1.73 m 2 .…”

Section: Markers Of Kidney Damagementioning

confidence: 77%

Chronic Kidney Disease Update

Kazmi¹,

Danial²

2012

Topics in Renal Biopsy and Pathology

View full text Add to dashboard Cite

“…Spot urine protein/creatinine relation can be interpreted as follows: normal ratio < 0.2g protein per gram creatinine (which correlates with 0.2g protein/day); nephrotic range ratio > 3.5 (which correlates with 3.5g protein). 300mg/day or higher is obviously abnormal and this higher value correlates to an approximate PCR of 0.2mg/mg (200mg/g) [72][73][74][75][76][77][78][79][80][81].…”

Section: Discussionmentioning

confidence: 99%

Association of Diabetic Retinopathy and Maculopathy with Elevated HbA1c, Blood Pressure, Serum Creatinine, Microalbuminuria, Spot Urine Protein, Nephropathy and Diabetic Kidney Disease. An Experience from Data Analysis of 10,580 Diabetic Patients

Aziz¹

2018

JED

View full text Add to dashboard Cite

show abstract

Quantitation of proteinuria with urinary protein/creatinine ratios and random testing with dipsticks in nephrotic children

Cited by 107 publications

References 13 publications

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Chronic Kidney Disease Update

Association of Diabetic Retinopathy and Maculopathy with Elevated HbA1c, Blood Pressure, Serum Creatinine, Microalbuminuria, Spot Urine Protein, Nephropathy and Diabetic Kidney Disease. An Experience from Data Analysis of 10,580 Diabetic Patients

Contact Info

Product

Resources

About