Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package

Su, Dan; Cesare, F Di; Andrasescu, A; Popa, E.; Lazariev, Andrii; Vescovo, E.; Štrbák, Oliver; Williams, S. R.; Starčuk, Zenon; Cabañas, Miquel E.; Ormondt, D. van; Graveron‐Demilly, D.

doi:10.1088/0957-0233/20/10/104035

Cited by 428 publications

(375 citation statements)

References 25 publications

(34 reference statements)

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“…Spectral data were post-processed by magnetic resonance user interface software (jMRUI, version 4.0; www.jmrui.eu [25,26]) by an assessor (NAJ) who was blinded to participant details and time point. Liver and pancreas water signal amplitudes were quantified using Hankel-Lanczos squares singular values decomposition [27][28][29], and a five resonance model was employed to fit the lipid peaks [24,27,30].…”

Section: Assessmentsmentioning

confidence: 99%

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

et al. 2016

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Aims/hypothesis The aim of the study was to investigate whether a very-low-energy diet (VLED) is a feasible and acceptable treatment option for type 2 diabetes in children and adolescents, and whether adherence can lead to rapid weight loss, reversal of type 2 diabetes and reduced liver fat as seen in adult studies. Methods Eight participants with type 2 diabetes and obesity, aged 7-16 years, non-medicated (n = 1) or treated with metformin (n = 7) and in some cases insulin (n = 3), followed a VLED (<3360 kJ/day) for 8 weeks, then transitioned to a hypocaloric diet (∼6300 kJ/day) that they followed to 34 weeks. HbA 1c , fasting glucose and 2 h post-glucose load plasma glucose (2hG) were determined from fasting blood and an OGTT. Liver fat concentration was quantified using proton magnetic resonance spectroscopy. Adherence was defined as ≥5% weight loss during the 8 week VLED. Results Adherers (n = 5) and non-adherers (n = 3) had median weight loss of 7.5% and 0.5%, respectively, at 8 weeks. Only three out of eight participants met non-alcoholic fatty liver disease (NAFLD) criteria (≥5.5%) at 8 weeks, compared with eight out of eight at baseline. The three participants on insulin therapy at baseline were able to cease therapy during the 8 week VLED. At 34 weeks, adherers (n = 5) achieved 12.3% weight loss, none met NAFLD criteria and four did not meet American Diabetes Association criteria for type 2 diabetes.

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Section: Assessmentsmentioning

confidence: 99%

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

et al. 2016

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“…We obtained 1 H magnetic resonance spectra using point-resolved spectroscopy with the following parameters: repetition time 1,500 ms, echo time 135 ms without water suppression and with 128 signal averages, and a 15 3 15 3 15 mm voxel size. Spectra were analyzed using the advanced method for accurate, robust, and efficient spectral fitting (AMARES) algorithm in the MRUI software package, version 5 (17). Peak areas for water and lipid resonances were obtained, and T1 and T2 corrections were performed (18).…”

Section: Mri Proceduresmentioning

confidence: 99%

Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus

Logan

Jeffries

et al. 2016

Diabetes Care

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OBJECTIVEInfants born to mothers with gestational diabetes mellitus (GDM) are at greater risk of later adverse metabolic health. We examined plausible candidate mediators, adipose tissue (AT) quantity and distribution and intrahepatocellular lipid (IHCL) content, comparing infants of mothers with GDM and without GDM (control group) over the first 3 postnatal months. RESEARCH DESIGN AND METHODSWe conducted a prospective longitudinal study using MRI and spectroscopy to quantify whole-body and regional AT volumes, and IHCL content, within 2 weeks and 8-12 weeks after birth. We adjusted for infant size and sex and maternal prepregnancy BMI. Values are reported as the mean difference (95% CI). RESULTSWe recruited 86 infants (GDM group 42 infants; control group 44 infants). Mothers with GDM had good pregnancy glycemic control. Infants were predominantly breast-fed up to the time of the second assessment (GDM group 71%; control group 74%). Total AT volumes were similar in the GDM group compared with the control group at a median age of 11 days (228 cm 3 [95% CI 2121, 65], P = 0.55), but were greater in the GDM group at a median age of 10 weeks (247 cm 3 [56, 439], P = 0.01). After adjustment for size, the GDM group had significantly greater total AT volume at 10 weeks than control group infants (16.0% [6.0, 27.1], P = 0.002). AT distribution and IHCL content were not significantly different at either time point. CONCLUSIONSAdiposity in GDM infants is amplified in early infancy, despite good maternal glycemic control and predominant breast-feeding, suggesting a potential causal pathway to later adverse metabolic health. Reduction in postnatal adiposity may be a therapeutic target to reduce later health risks.Diabetes in pregnancy is increasing and currently affects up to 5% of women in the U.K.(1) and up to 9.2% in the U.S. (2). Approximately 87.5% of cases are gestational diabetes mellitus (GDM), 7.5% are type 1 diabetes, and 5% are type 2 diabetes (1). The offspring of mothers with diabetes have greater risks of adverse metabolic sequelae in childhood and later life that appear to be additional to genetic predisposition (3-5).The underlying mechanisms are unclear, but increased infant adiposity is a plausible mediator because adiposity in childhood and adult life are associated with type 2 diabetes and cardiovascular disease (6). The Hyperglycemia and Adverse

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“…SV data was processed using jMRUI [34] in version 5.0. Individually stored acquisitions were averaged and the residual water signal was removed by Henkel Lankos Singular Value Decomposition (HLSVD) before modeling with QUEST [35].…”

Section: Mrs Data Processingmentioning

confidence: 99%

Magnetic resonance spectroscopy investigations of functionally defined language areas in schizophrenia patients with and without auditory hallucinations

et al. 2014

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Background: Cerebral dysfunction occurring in mental disorders can show metabolic disturbances which are limited to circumscribed brain areas. Auditory hallucinations have been shown to be related to defined cortical areas linked to specific language functions. Here, we investigated if the study of metabolic changes in auditory hallucinations requires a functional rather than an anatomical definition of their location and size to allow a reliable investigation by magnetic resonance spectroscopy (MRS). Methods: Schizophrenia patients with (AH; n=12) and without hallucinations (NH; n=8) and healthy controls (HC; n=11) underwent a verbal fluency task in functional MRI (fMRI) to functionally define Broca's and Wernicke's areas. Left and right Heschl's gyrus were defined anatomically. Results: The mean distances in native space between the fMRI-defined regions and a corresponding anatomically defined area were 12.4±6.1 mm (range: 2.7-36.1 mm) for Broca's area and 16.8±6.2 mm (range:4.5-26.4 mm) for Wernicke's area, respectively. Hence, the spatial variance was of similar extent as the size of the investigated regions. Splitting the investigations into a single voxel examination in the frontal brain and a spectroscopic imaging part for the more homogeneous field areas led to good spectral quality for almost all spectra. In Broca's area, there was a significant group effect (p = 0.03) with lower levels of N-acetyl-aspartate (NAA) in NH compared to HC (p = 0.02). There were positive associations of NAA levels in the left Heschl's gyrus with total (p = 0.03) and negative (p = 0.006) PANSS scores. In Broca's area, there was a negative association of myo-inositol levels with total PANSS scores (p = 0.008). Conclusion: This study supports the neurodegenerative hypothesis of schizophrenia only in a frontal region whereas the results obtained from temporal regions are in contrast to the majority of previous studies. Future research should test the hypothesis raised by this study that a functional definition of language regions is needed if neurochemical imbalances are expected to be restricted to functional foci. Highlights

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Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package

Cited by 428 publications

References 25 publications

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus

Magnetic resonance spectroscopy investigations of functionally defined language areas in schizophrenia patients with and without auditory hallucinations

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